TOX Rat anti-Mouse, eFluor 660, Clone: TXRX10, eBioscience™

Rat Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 50-6502-82

Code: NEW

Additional Details:
Additional Details: Weight: 0.09500kg



Disclaimers: For Research Use Only.

Product Code. 15510007

Quantity Price
1 £ 231.74 / 100µg
Estimated Shipment date
from Supplier 03-04-2017
Add to basket


Description and Specification

Specification

Conjugate eFluor 660
Regulatory Status RUO
Species Reactivity Mouse
Gene Alias Thymocyte selection-associated HMG box protein
Isotype IgG2a
Quantity 100μg
Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material.
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Concentration 0.2mg/mL
Host Species Rat
Monoclonal or Polyclonal Monoclonal
Clone TXRX10
Primary or Secondary Primary
Format Conjugated
Applications Flow Cytometry (Intracellular Staining)
Antigen TOX

This TXRX10 monoclonal antibody reacts with human and mouse TOX, which is also known as Thymocyte selection-associated HMG box protein. This DNA-binding nuclear factor is expressed in thymocytes, T lymphocytes, NK cells, and lymphoid tissue-inducer (LTi) cells. TOX expression in thymocytes is upregulated during beta-selection and positive selection. Studies using Tox knockout mice have demonstrated a critical role for TOX in CD4+ T cell development as a regulator of the CD4loCD8lo to CD4+CD8lo transition. Moreover, TOX has been shown to be involved in the development of NK and LTi cells. While its regulation remains unclear, TOX expression has been shown to be induced by calcineurin-mediated TCR signaling in thymocytes during positive selection.