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TOX Rat anti-Mouse, Clone: TXRX10, eBioscience™

Rat Monoclonal Antibody

Brand:  Affymetrix eBioscience 14-6502-82

Code : Z2

Additional Details : Weight : 0.01000kg

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Product Code. 15247717

  • £109.45 / 100µg


Estimated Shipment
28-11-2017
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Disclaimers:

For Research Use Only.


Description

Description

This TXRX10 monoclonal antibody reacts with human and mouse TOX, which is also known as Thymocyte selection-associated HMG box protein. This DNA-binding nuclear factor is expressed in thymocytes, T lymphocytes, NK cells, and lymphoid tissue-inducer (LTi) cells. TOX expression in thymocytes is upregulated during β-selection and positive selection. Studies using Tox knockout mice have demonstrated a critical role for TOX in CD4+ T cell development as a regulator of the CD4loCD8lo to CD4+CD8lo transition. Moreover, TOX has been shown to be involved in the development of NK and LTi cells. While its regulation remains unclear, TOX expression has been shown to be induced by calcineurin-mediated TCR signaling in thymocytes during positive selection.
Specifications

Specifications

TOX
TXRX10
Unconjugated
Purified
Rat
100μg
Store at 2-8°C.
Monoclonal
Western Blot
0.5mg/mL
aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Thymocyte selection-associated HMG box protein
IgG2a
RUO
Primary
Murine