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TNF alpha, Functional Grade, clone: MP6-XT3, eBioscience™

Rat Monoclonal Antibody

Brand:  Affymetrix eBioscience 16-7322-81

Code : Z2

Additional Details : Weight : 0.01000kg

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Product Code. 15288797

  • £62.06 / 50µg


EU Stock 2
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Disclaimers:

For Research Use Only.


Description

Description

Description: The MP6-XT3 monoclonal antibody reacts with mouse Tumor Necrosis Factor-alpha (TNF-alpha), a 17kDa cytokine produced by monocytes, macrophages, neutrophils, NK cells and CD4^+ T cells. TNF alpha has cytolytic activity against a range of tumor cells and is important in immune regulation. TNF alpha forms dimers and trimers and also exists as a 26kDa membrane-bound form.Applications Reported: The MP6-XT3 antibody has been reported for use in cytokine neutralization.Applications Tested: The Functional Grade Purified MP6-XT3 antibody has been tested by LAL assay to verify low endotoxin level and has been tested for neutralization of TNF alpha bioactivity. The MP6-XT3 antibody at 0.60 μg/mL has been found to neutralize by 50% the biological effects of 1.0 ng/mL mouse TNF alpha in an assay of TNF alpha induced cytotoxicity of L929 cells. Detailed information and protocols about cytokine bioassays and in vitro cytokine neutralization using antibodies can be found in the BestProtocols® section. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest.Endotoxin: Less than 0.001 ng/ug antibody as determined by the LAL assay.Storage and handling: Use in a sterile environment.Filtration: 0.2μm post-manufacturing filtered.Purity: Greater than 90%, as determined by SDS-PAGE.Endotoxin Level: Less than 0.001 ng/μg antibody, as determined by LAL assay.Aggregation: Less than 10%, as determined by HPLC.
Specifications

Specifications

TNF alpha
MP6-XT3
Unconjugated
Purified
Rat
50μg
Store at 2-8°C.
Monoclonal
Cytokine Neutralization
1mg/mL
aqueous buffer, no sodium azide
Tumor Necrosis Factor alpha
IgG1
RUO
Primary
Murine
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