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TNF alpha Mouse anti-Human, PE, Clone: MAb11, eBioscience™

Mouse Monoclonal Antibody

£65.50 - £89.25

Specifications

Antigen TNF alpha
Clone MAb11
Target Species Human
Conjugate PE
Isotype IgG1, kappa
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Products 2
Product Code Brand Quantity Price Quantity & Availability  
Product Code Brand Quantity Price Quantity & Availability  
15577116
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Affymetrix eBioscience
12-7349-41
25 Tests £65.50
25 tests View alternative products
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Estimated Shipment
02-11-2020
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15209329
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Affymetrix eBioscience
12-7349-81
50μg £89.25
50µg View alternative products
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In stock, ready to ship: 1 Please to purchase this item. Need a web account? Register with us today!
Description

Description

It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest. - test size: has been pre-titrated and tested by intracellular staining and flow cytometric analysis of stimulated normal human peripheral blood cells. This can be used at 5 μL (0.25 μg) per test. A test is defined as the amount (μg) of antibody that will stain a cell sample in a final volume of 100 μL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. Excitation: 488-561 nm; Emission: 578 nm; Laser: Blue Laser, Green Laser, Yellow-Green Laser. Filtration: 0.2 μm post-manufacturing filtered. TNF alpha is a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. This cytokine is mainly secreted by macrophage and bind to its receptors, TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. TNF alpha is involved in the regulation of immune cells, cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. TNF alpha exists as a multimer of two, three, or five noncovalently linked units, but shows a single 17 kDa band following SDS-PAGE under non-reducing conditions. Knockout studies in mice also suggested the neuroprotective function of TNF alpha, and has been observed to causes tumor necrosis when injected into tumor-bearing mice. Other functions of TNF-alpha include its role in the immune response to bacterial, viral, parasitic and certain fungal infections, as well as its role in the necrosis of specific tumors. TNF alpha causes cytolysis or cytostasis of certain transformed cells, being synergistic with interferon-gamma in its cytotoxicity. This cytokine has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, and cancer.
Specifications

Specifications

TNF alpha
Human
IgG1, kappa
Monoclonal
Conjugated
Store at 2-8°C. Do not freeze. Light-sensitive material.
MAb11
PE
Flow Cytometry
Primary
aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
RUO

For Research Use Only.