TL1A Mouse anti-Human, Mouse, PerCP-eFluor 710, Clone: Tandys1a, eBioscience™

Mouse Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 46-7911-80

UNSPSC: 12352200

Code: Z2

Additional Details:
Additional Details: Weight: 0.25000kg



Disclaimers: For Research Use Only.

Product Code. 15301400

Quantity Price
1 £ 81.63 / 25µg
Estimated Shipment date
from Supplier 02-05-2017
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Description and Specification

Specification

Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material.
Quantity 25μg
Isotype IgG1
Antigen TL1A
Clone Tandys1a
Primary or Secondary Primary
Gene Alias TNFSF15, VEGI, Tumor necrosis factor ligand superfamily member 15
Host Species Mouse
Regulatory Status RUO
Conjugate PerCP-eFluor 710
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Concentration 0.2mg/mL
Monoclonal or Polyclonal Monoclonal
Format Conjugated
Applications Flow Cytometry
Applications Flow Cytometry (Intracellular Staining)
Species Reactivity Human, Mouse

The Tandys1a monoclonal antibody reacts with human and mouse TL1A (TNFSF15). TL1A is a member of the TNF ligand family and is expressed by endothelial cells, tissue macrophages, monocyte-derived dendritic cells, plasma cells and lamina propria-derived lymphocytes. Among peripheral blood cells, TL1A has been shown to be expressed predominantly by CD4+CCR9+ lymphocytes. Its expression has been shown to be induced by TNF alpha, IL-1 alpha and IFN gamma. TL1A binds DR3, which has been shown to be specifically upregulated in Th17 cells among CD4+ T cells. TL1A-deficient dendritic cells are weak in their ability to support Th17 cells in vitro and show decreased severity of EAE. In vivo, TL1A has been shown to be upregulated in tissue lymphocytes of Crohn’s Disease and ulcerative colitis patients.