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TL1A Mouse anti-Human, Mouse, PerCP-eFluor 710, Clone: Tandys1a, eBioscience™

Mouse Monoclonal Antibody

Brand:  Affymetrix eBioscience 46-7911-82

UNSPSC : 12352200

Code : Z2

Additional Details : Weight : 0.25000kg

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Product Code. 15311400

  • £201.85 / 100µg


Estimated Shipment
07-07-2017
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Disclaimers:

For Research Use Only.


Specifications

Description

The Tandys1a monoclonal antibody reacts with human and mouse TL1A (TNFSF15). TL1A is a member of the TNF ligand family and is expressed by endothelial cells, tissue macrophages, monocyte-derived dendritic cells, plasma cells and lamina propria-derived lymphocytes. Among peripheral blood cells, TL1A has been shown to be expressed predominantly by CD4+CCR9+ lymphocytes. Its expression has been shown to be induced by TNF alpha, IL-1 alpha and IFN gamma. TL1A binds DR3, which has been shown to be specifically upregulated in Th17 cells among CD4+ T cells. TL1A-deficient dendritic cells are weak in their ability to support Th17 cells in vitro and show decreased severity of EAE. In vivo, TL1A has been shown to be upregulated in tissue lymphocytes of Crohn’s Disease and ulcerative colitis patients.
Description & Specifications

Specifications

TL1A
Tandys1a
PerCP-eFluor 710
aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Murine
100μg
Store at 2-8°C. Do not freeze. Light-sensitive material.
Monoclonal
Flow Cytometry (Intracellular Staining)
0.2mg/mL
Conjugated
TNFSF15, VEGI, Tumor necrosis factor ligand superfamily member 15
IgG1
RUO
Primary
Murine