TIM-4 Rat anti-Mouse, PerCP-eFluor™ 710, Clone: 54 (RMT4-54), eBioscience™
Rat Monoclonal Antibody
Brand: Affymetrix eBioscience 46-5866-80
Code : NEW
Additional Details : Weight : 0.09500kg
DescriptionPlease make sure that your instrument is capable of detecting this fluorochrome. Fixation: Samples can be stored in IC Fixation Buffer (cat. 00-8222) (100 µL cell sample + 100 µL IC Fixation Buffer) or 1-step Fix/Lyse Solution (cat. 00-5333) for up to 3 days in the dark at 4°C with minimal impact on brightness and FRET efficiency/compensation. Some generalizations regarding fluorophore performance after fixation can be made, but clone specific performance should be determined empirically. Excitation: 488 nm; Emission: 710 nm; Laser: Blue Laser. Filtration: 0.2 μm post-manufacturing filtered. The T cell immunoglobulin and mucin domain containing protein (TIM) family encodes cell surface receptors that are involved in the regulation of T helper (Th) -1 and -2 cell-mediated immunity. TIM-4, which is preferentially expressed on macrophages and dendritic cells, is the natural ligand of TIM-1, and this binding leads to T-cell expansion and cytokine production. Unlike other members of the TIM family, TIM-4 lacks a putative tyrosine phosphorylation signal sequence in its intracellular domain. The TIM-4 gene maps to a locus associated with predisposition to asthma in both mice and humans and with its connection to TIM-1-triggered Th2 responsiveness, may be considered as a candidate disease/predisposition gene for asthma.
|PBS with 0.1% gelatin and 0.09% sodium azide; pH 7.2|
|SMUCKLER, TIM4; T-cell immunoglobulin and mucin domain-containing protein 4; T-cell membrane protein 4; TIM-4; TIMD-4|
|4° C, store in dark, DO NOT FREEZE!|
For Research Use Only.