TIGIT Mouse anti-Human, PerCP-eFluor 710, Clone: MBSA43, eBioscience™

Mouse Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 46-9500-42

Code: NEW

Additional Details:
Additional Details: Weight: 0.23750kg



Disclaimers: For Research Use Only.

Product Code. 15549426

Quantity Price
1 £ 237.72 / 100 tests
EU Stock 62
Add to basket


Description and Specification

Specification

Quantity 100 Tests
Host Species Murine
Isotype IgG1
Conjugate PerCP-eFluor 710
Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material. This tandem dye is sensitive to photo-induced oxidation. Protect this vial from light during storage
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Clone MBSA43
Format Conjugated
Regulatory Status RUO
Antigen TIGIT
Applications Flow Cytometry
Gene Alias VSTM3, WUCAM
Monoclonal or Polyclonal Monoclonal
Species Reactivity Human
Primary or Secondary Primary
Concentration 5μL (0.125μg)/test

The MBSA43 monoclonal antibody reacts with human T cell immunoreceptor with Ig and ITIM domains (TIGIT), which is also known as VSTM3 or WUCAM. This 26kDa protein is a member of the poliovirus receptor (PVR) family. The expression of TIGIT has been reported on NK cells, regulatory T cells, follicular T helper cells, memory CD4+ T cells, and CD8+ T cells, but it is not expressed on B cells or naïve CD4+ T cells. TIGIT may be upregulated on naïve CD4+ T cells upon activation. TIGIT can interact with certain members of the PVR and PVR-like families, including CD155, and also mediates the interaction of NK and T cells with antigen presenting cells, fibroblasts, and endothelial cells that express PVR and PVR-like proteins.

MBSA43 is reported to crossreact with Rhesus macaque.