tigit Mouse anti-Human, Clone: MBSA43, Functional Grade, eBioscience™

Mouse Monoclonal Antibody, Functional Grade

Brand: Affymetrix eBioscience

Manufacturer Part Number: 16-9500-85

UNSPSC: 12352200

Code: Z2

Additional Details:
Additional Details: Weight: 0.01000kg

Disclaimers: For Research Use Only.

Product Code. 15288827

Quantity Price
1 £ 213.39 / 500µg
EU Stock 14
Add to basket

Description and Specification


Host Species Murine
Formulation aqueous buffer, no sodium azide
Regulatory Status RUO
Clone MBSA43
Conjugate Unlabeled
Gene Alias VSTM3, WUCAM
Storage Requirements Store at 2-8°C.
Primary or Secondary Primary
Applications Flow Cytometry
Applications Functional Assay
Antigen tigit
Species Reactivity Human
Format Purified
Isotype IgG1
Quantity 500μg
Concentration 1mg/mL
Monoclonal or Polyclonal Monoclonal

The MBSA43 monoclonal antibody reacts with human T cell immunoreceptor with Ig and ITIM domains (TIGIT), which is also known as VSTM3 or WUCAM. This 26kDa protein is a member of the poliovirus receptor (PVR) family. The expression of TIGIT has been reported on NK cells, regulatory T cells, follicular T helper cells, memory CD4+ T cells, and CD8+ T cells, but it is not expressed on B cells or naïve CD4+ T cells. TIGIT may be upregulated on naïve CD4+ T cells upon activation. TIGIT can interact with certain members of the PVR and PVR-like families, including CD155, and also mediates the interaction of NK and T cells with antigen presenting cells, fibroblasts, and endothelial cells that express PVR and PVR-like proteins.

MBSA43 is reported to crossreact with Rhesus macaque.