tigit Mouse anti-Human, Clone: MBSA43, Functional Grade, eBioscience™

Mouse Monoclonal Antibody, Functional Grade

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 16-9500-85

UNSPSC: 12352200

Code: Z2

Additional Details:
Additional Details: Weight: 0.01000kg



Disclaimers: For Research Use Only.

Product Code. 15288827

Quantity Price
1 £ 213.39 / 500µg
EU Stock 14
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Description and Specification

Specification

Host Species Murine
Formulation aqueous buffer, no sodium azide
Regulatory Status RUO
Clone MBSA43
Conjugate Unlabeled
Gene Alias VSTM3, WUCAM
Storage Requirements Store at 2-8°C.
Primary or Secondary Primary
Applications Flow Cytometry
Applications Functional Assay
Antigen tigit
Species Reactivity Human
Format Purified
Isotype IgG1
Quantity 500μg
Concentration 1mg/mL
Monoclonal or Polyclonal Monoclonal

The MBSA43 monoclonal antibody reacts with human T cell immunoreceptor with Ig and ITIM domains (TIGIT), which is also known as VSTM3 or WUCAM. This 26kDa protein is a member of the poliovirus receptor (PVR) family. The expression of TIGIT has been reported on NK cells, regulatory T cells, follicular T helper cells, memory CD4+ T cells, and CD8+ T cells, but it is not expressed on B cells or naïve CD4+ T cells. TIGIT may be upregulated on naïve CD4+ T cells upon activation. TIGIT can interact with certain members of the PVR and PVR-like families, including CD155, and also mediates the interaction of NK and T cells with antigen presenting cells, fibroblasts, and endothelial cells that express PVR and PVR-like proteins.

MBSA43 is reported to crossreact with Rhesus macaque.