tigit Mouse anti-Human, Clone: MBSA43, Functional Grade, eBioscience™

Mouse Monoclonal Antibody, Functional Grade

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 16-9500-82

UNSPSC: 12352200

Code: Z2

Additional Details:
Additional Details: Weight: 0.01000kg



Disclaimers: For Research Use Only.

Product Code. 15278827

Quantity Price
1 £ 60.53 / 100µg
EU Stock 4
Add to basket


Description and Specification

Specification

Applications Flow Cytometry
Applications Functional Assay
Regulatory Status RUO
Gene Alias VSTM3, WUCAM
Clone MBSA43
Format Purified
Storage Requirements Store at 2-8°C.
Isotype IgG1
Concentration 1mg/mL
Monoclonal or Polyclonal Monoclonal
Quantity 100μg
Formulation aqueous buffer, no sodium azide
Conjugate Unlabeled
Species Reactivity Human
Host Species Mouse
Antigen tigit
Primary or Secondary Primary

The MBSA43 monoclonal antibody reacts with human T cell immunoreceptor with Ig and ITIM domains (TIGIT), which is also known as VSTM3 or WUCAM. This 26kDa protein is a member of the poliovirus receptor (PVR) family. The expression of TIGIT has been reported on NK cells, regulatory T cells, follicular T helper cells, memory CD4+ T cells, and CD8+ T cells, but it is not expressed on B cells or naïve CD4+ T cells. TIGIT may be upregulated on naïve CD4+ T cells upon activation. TIGIT can interact with certain members of the PVR and PVR-like families, including CD155, and also mediates the interaction of NK and T cells with antigen presenting cells, fibroblasts, and endothelial cells that express PVR and PVR-like proteins.

MBSA43 is reported to crossreact with Rhesus macaque.