Invitrogen™ Human TNF-alpha Recombinant Protein

Recombinant Protein

Brand:  Invitrogen™ RP75738

Product Code. 11559051

Description

TNF alpha (human) Recombinant Protein, RP-75738, from Invitrogen.

TNF alpha is a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. This cytokine is mainly secreted by macrophage and bind to its receptors, TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. TNF alpha is involved in the regulation of immune cells, cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. TNF alpha exists as a multimer of two, three, or five noncovalently linked units, but shows a single 17 kDa band following SDS-PAGE under non-reducing conditions. Knockout studies in mice also suggested the neuroprotective function of TNF alpha, and has been observed to causes tumor necrosis when injected into tumor-bearing mice. Other functions of TNF-alpha include its role in the immune response to bacterial, viral, parasitic and certain fungal infections, as well as its role in the necrosis of specific tumors. TNF alpha causes cytolysis or cytostasis of certain transformed cells, being synergistic with interferon-gamma in its cytotoxicity. This cytokine has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, and cancer. RP-75738 contains purified recombinant human TNF alpha protein with an N-terminal hexahistidine tag. RP-75738 may be used as a positive control in many immunological assays.

Specifications

• Accession Number: P01375
• Formulation: 20mM tris HCl with 50% glycerol and no preservative; pH 8
• Name: Human TNF alpha
• Quantity: 1mg
• Immunogen: N/A
• Regulatory Status: RUO
• Gene Symbol: TNF
• Conjugate: Unconjugated
• Species: E. coli
• Form: Liquid
• Purity or Quality Grade: purified

• For Use With (Application): Control, Western Blot
• Gene ID (Entrez): 7124
• pH Range: 8
• Source: E. coli
• Storage Requirements: -20°C, Avoid Freeze/Thaw Cycles
• Common Name: Human TNF alpha
• Specific Reactivity: Human
• Cross Reactivity: Hu
• Recombinant: Recombinant
• Protein Subtype: Recombinant

in vitro research only.