Invitrogen™ Human Protein C Native Protein

Native Protein

Brand:  Invitrogen™ RP43084

Product Code. 11534121

Description

Protein C (human) Native Protein, RP-43084, from Invitrogen.

Protein C is a vitamin K-dependent plasma glycoprotein that is cleaved to its activated form by the thrombin-thrombomodulin complex. Protein C in its activated form contains a serine protease domain and functions in degradation of the activated forms of coagulation factors V and VIII. Protein C is a vitamin K-dependent serine protease produced in the liver and made up of 2 polypeptide chains. The 62 kDa proenzyme is activated by thrombin bound to an endothelial surface receptor and the active enzyme cleaves factor Va and VIIIa and thus inhibits blood coagulation. The molecular weight of the active enzyme is 55 kDa and the normal concentrations in human plasma is approximately 1-3ng/mL because of the very fast turnover, the proenzyme concentration is approximately 3ug/mL. Mutations in the Protein C gene have been associated with thrombophilia due to protein C deficiency, neonatal purpura fulminans, and recurrent venous thrombosis. RP-43084 contains native human Protein C protein. RP-43084 may be used as a positive control in many immunological assays. The RP-43084 protein molecular weight is ∽62 kDa. The product is of human blood/plasma origin. Although the starting material was tested prior to initiation of the manufacturing process, and was found negative or nonreactive for anti-HIV-1/2, HIV-1 antigen(s), HBsAg, STS, anti-HCV, anti-HBcore and anti-HTLV I & II, extreme caution should be used when handling this material as there is a margin of error in all tests. This product is to be used for IN VITRO research purposes only, and is not intended for clinical or diagnostic use!

Specifications

• Accession Number: P04070
• Formulation: 50%water with 50% glycerol and no preservative
• Molecular Weight (g/mol): ∽62
• Quantity: 100μg
• Storage Requirements: -20°C, Avoid Freeze/Thaw Cycles
• Common Name: Human Protein C
• Specific Reactivity: Human
• Cross Reactivity: Hu
• Recombinant: Native
• Protein Subtype: Native

• For Use With (Application): Control
• Gene ID (Entrez): 5624
• Name: Human Protein C
• Source: Human
• Regulatory Status: RUO
• Gene Symbol: PROC
• Conjugate: Unconjugated
• Species: Human
• Form: Liquid
• Purity or Quality Grade: purified

in vitro research only.