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TG 003, Tocris Bioscience™

Potent inhibitor of Clk-family kinases; also inhibits DYRK1A/B

Brand:  RD Systems (Bio-Techne) 4336/10

Code : Z1

Additional Details : Weight : 0.00010kg

Quantity 10mg

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Product Code. 13444574

  • £175.56 / 10mg

Estimated Shipment date
from Supplier 24-09-2019

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Description

Description

Potent, ATP-competitive inhibitor of Clk-family kinases (IC50 values are 15, 20 and 200 nM for mClk4, 1 and 2 respectively and >10 μM for mClk3). Also inhibits DYRK1A/B (IC50 values are 24 and 34 nM respectively). Suppresses serine/arginine-rich protein phosphorylation; affects the regulation of alternative splicing by phosphorylation of SR protein both in vitro and in vivo.
Specifications

Chemical Identifiers

719277-26-6
249.328
clk inhibitor, clk inhibitor, tg003, z-1-3-ethyl-5-methoxy-2,3-dihydrobenzothiazol-2-ylidene propan-2-one, 1z-1-3-ethyl-5-methoxy-1,3-benzothiazol-2-ylidene propan-2-one, cdc2-like kinase inhibitor, tg003, z-1-3-ethyl-5-methoxybenzo d thiazol-2 3h-ylidene propan-2-one, cdc2-like kinase inhibitor, 1-2z-3-ethyl-5-methoxy-1,3-benzothiazol-2-ylidene propan-2-one, d06mbi, 1-3-ethyl-5-methoxy-2 3h-benzothiazolylidene-2-propanone
(1Z)-1-(3-ethyl-5-methoxy-1,3-benzothiazol-2-ylidene)propan-2-one
C13H15NO2S
BGVLELSCIHASRV-QPEQYQDCSA-N
1893668
CCN1C2=C(C=CC(=C2)OC)SC1=CC(=O)C

Specifications

TG 003
719277-26-6
clk inhibitor, clk inhibitor, tg003, z-1-3-ethyl-5-methoxy-2,3-dihydrobenzothiazol-2-ylidene propan-2-one, 1z-1-3-ethyl-5-methoxy-1,3-benzothiazol-2-ylidene propan-2-one, cdc2-like kinase inhibitor, tg003, z-1-3-ethyl-5-methoxybenzo d thiazol-2 3h-ylidene propan-2-one, cdc2-like kinase inhibitor, 1-2z-3-ethyl-5-methoxy-1,3-benzothiazol-2-ylidene propan-2-one, d06mbi, 1-3-ethyl-5-methoxy-2 3h-benzothiazolylidene-2-propanone
CCN1C2=C(C=CC(=C2)OC)SC1=CC(=O)C
249.328
249.33
10mg
C13H15NO2S
BGVLELSCIHASRV-QPEQYQDCSA-N
(1Z)-1-(3-ethyl-5-methoxy-1,3-benzothiazol-2-ylidene)propan-2-one
1893668
>98%
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