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Tocris Bioscience™ TFB-TBOA

High affinity EAAT1 and EAAT2 blocker

Brand:  Tocris Bioscience™ 253210

Code : Z1

Additional Details : Weight : 0.00150kg

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Product Code. 13431414

  • £292.53 / 10mg

Estimated Shipment date
from Supplier 30-03-2020

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Description

Description

Potent and selective glial glutamate transporter EAAT1 and EAAT2 inhibitor (IC50 values are 17, 22 and 300 nM for EAAT2, EAAT1 and EAAT3 respectively). Has no effect on EAAT4 and EAAT5, or a wide range of neuronal receptors and transporters. Attenuates glutamate-stimulated intracellular Na+ elevation in astrocytes in vitro (IC50 = 43 nM). Induces severe convulsions in vivo.
Specifications

Specifications

(3S)-3-[[3-[[4-(Trifluoromethyl)benzoyl]amino]phenyl]methoxy]-L-aspartic acid
>98%
Observed MW: 426.35
Soluble to 100mM in DMSO
480439-73-4
C19H17F3N2O6
10mg
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