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TdT Mouse, Clone: 7UNA8U6, eBioscience™

Mouse Monoclonal Antibody

Brand:  Affymetrix eBioscience 14-9739-80

Code : NEW

Additional Details : Weight : 0.09500kg

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Product Code. 15547616

  • £61.70 / 25µg


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For Research Use Only.


Description

Description

The monoclonal antibody 7UNA8U6 reacts with human, mouse, and rat TdT. TdT, or terminal-deoxynucleotidyl transferase, is a 60kDa polymerase responsible for the template-independent addition of N-nucleotides at gene segment junctions of developing lymphocytes. Expression is found in the nucleus of immature lymphocytes but not in mature lymphocytes or non-lymphoid cells. TdT plays a critical role during TCR and Ig gene rearrangement and functions to increase the diversity of the lymphocyte repertoire through the addition of N-nucleotides onto the ends of newly formed P-nucleotides. After positive selection, expression of TdT becomes decreased or absent. Expression of TdT has been shown to be present in lymphoma or lymphoblastic leukemia cells.
Specifications

Specifications

TdT
7UNA8U6
Unlabeled
Purified
Murine
25μg
Store at 2-8°C.
Monoclonal
Western Blot
0.5mg/mL
aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Terminal-deoxynucleotidyl transferase
IgG1
RUO
Primary
Rat
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