TdT Mouse, Clone: 7UNA8U6, eBioscience™

Mouse Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 14-9739-80

Code: NEW

Additional Details:
Additional Details: Weight: 0.09500kg



Disclaimers: For Research Use Only.

Product Code. 15547616

Quantity Price
1 £ 61.7 / 25µg
Estimated Shipment date
from Supplier 03-05-2017
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Description and Specification

Specification

Applications Immunohistochemistry
Applications Immunohistochemistry (Formalin/Paraffin)
Applications Western Blotting
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Isotype IgG1
Antigen TdT
Gene Alias Terminal-deoxynucleotidyl transferase
Host Species Mouse
Storage Requirements Store at 2-8°C.
Monoclonal or Polyclonal Monoclonal
Concentration 0.5mg/mL
Primary or Secondary Primary
Clone 7UNA8U6
Format Purified
Quantity 25μg
Conjugate Unlabeled
Regulatory Status RUO
Species Reactivity Human, Mouse, Rat

The monoclonal antibody 7UNA8U6 reacts with human, mouse, and rat TdT. TdT, or terminal-deoxynucleotidyl transferase, is a 60kDa polymerase responsible for the template-independent addition of N-nucleotides at gene segment junctions of developing lymphocytes. Expression is found in the nucleus of immature lymphocytes but not in mature lymphocytes or non-lymphoid cells. TdT plays a critical role during TCR and Ig gene rearrangement and functions to increase the diversity of the lymphocyte repertoire through the addition of N-nucleotides onto the ends of newly formed P-nucleotides. After positive selection, expression of TdT becomes decreased or absent. Expression of TdT has been shown to be present in lymphoma or lymphoblastic leukemia cells.