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TCS 21311, Tocris Bioscience™

Potent JAK3 inhibitor. Also inhibits GSK-3β and PKC

Brand:  RD Systems (Bio-Techne) 4221/10

Code : Z1

Additional Details : Weight : 0.00010kg

Quantity 10mg

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Product Code. 13444384

  • £194.04 / 10mg

Estimated Shipment date
from Supplier 28-10-2019

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Description

Description

Potent JAK3 inhibitor (IC50 = 8 nM). Selective for JAK3 over JAK1, JAK2 and TYK2 (IC50 values are 1017, 2550 and 8055 nM respectively). Also inhibits GSK-3β, PKCα and PKCθ (IC50 values are 3, 13 and 68 nM respectively).
Specifications

Chemical Identifiers

1260181-14-3
526.516
3-5-4-2-hydroxy-2-methyl-1-oxopropyl-1-piperazinyl-2-trifluoromethyl phenyl-4-1h-indol-3-yl-1h-pyrrole-2,5-dione, 3-5-4-2-hydroxy-2-methylpropanoyl piperazin-1-yl-2-trifluoromethyl phenyl-4-1h-indol-3-yl-1h-pyrrole-2,5-dione, 3-5-4-2-hydroxy-2-methyl-propionyl-piperazin-1-yl-2-trifluoromethyl-phenyl-4-1h-indol-3-yl-pyrrole-2,5-dione
3-[5-[4-(2-hydroxy-2-methylpropanoyl)piperazin-1-yl]-2-(trifluoromethyl)phenyl]-4-(1H-indol-3-yl)pyrrole-2,5-dione
C27H25F3N4O4
CLGRAWDGLMENOD-UHFFFAOYSA-N
50925411
CC(C)(C(=O)N1CCN(CC1)C2=CC(=C(C=C2)C(F)(F)F)C3=C(C(=O)NC3=O)C4=CNC5=CC=CC=C54)O

Specifications

10mg
1260181-14-3
3-5-4-2-hydroxy-2-methyl-1-oxopropyl-1-piperazinyl-2-trifluoromethyl phenyl-4-1h-indol-3-yl-1h-pyrrole-2,5-dione, 3-5-4-2-hydroxy-2-methylpropanoyl piperazin-1-yl-2-trifluoromethyl phenyl-4-1h-indol-3-yl-1h-pyrrole-2,5-dione, 3-5-4-2-hydroxy-2-methyl-propionyl-piperazin-1-yl-2-trifluoromethyl-phenyl-4-1h-indol-3-yl-pyrrole-2,5-dione
CC(C)(C(=O)N1CCN(CC1)C2=CC(=C(C=C2)C(F)(F)F)C3=C(C(=O)NC3=O)C4=CNC5=CC=CC=C54)O
526.516
526.51
TCS 21311
C27H25F3N4O4
CLGRAWDGLMENOD-UHFFFAOYSA-N
3-[5-[4-(2-hydroxy-2-methylpropanoyl)piperazin-1-yl]-2-(trifluoromethyl)phenyl]-4-(1H-indol-3-yl)pyrrole-2,5-dione
50925411
>98%
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