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T-bet Monoclonal Antibody (eBio4B10 (4B10)), PE-Cyanine7, eBioscience™, Invitrogen™

Mouse Monoclonal Antibody

£127.00 - £312.00

Specifications

Antigen T-bet
Clone eBio4B10 (4B10)
Concentration 0.2 mg/mL
Applications Flow Cytometry
Classification Monoclonal
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Products 2
Product Code Brand Quantity Price Quantity & Availability  
Product Code Brand Quantity Price Quantity & Availability  
15330980
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Affymetrix eBioscience
25-5825-80
25 μg
£127.00
25µg
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15340980
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Affymetrix eBioscience
25-5825-82
100 μg
£312.00
100µg
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Description

Description

Description: The eBio4B10 monoclonal antibody reacts with mouse and human T-bet. T-bet is a Th1-specific T-box transcription factor critical to the development of the Th1 CD4+ T cell lineage. This is known based on the observations that T-Bet deficient mice have impaired Th1 cell development, and that ectopic expression of T-Bet results in development skewed to the Th1 lineage. T-Bet expression is induced by the Th1 cytokine IFN gamma, and T-Bet also regulates the expression of IFN gamma, likely, at least in part, through the modification of DNA accessibility and histone remodeling. In addition to IFN gamma, T-Bet is also known to regulate the expression of IL-12R beta and IL-2. Moreover, T-Bet plays a role in class-switch recombination in B-cells. Applications Reported: This eBio4B10 (4B10, 4-B10) antibody has been reported for use in intracellular staining followed by flow cytometric analysis. Applications Tested: This eBio4B10 (4B10, 4-B10) antibody has been tested by intracellular stainign and flow cytometric analysis of normal human peripheral blood cells using the Foxp3/Transcription Factor Buffer Set (cat. 00-5523) and protocol. Please see Best Protocol section; (refer to Protocol B: One step protocol for intracellular (nuclear) proteins). This can be used at less than or equal to 0.125 μg per test. A test is defined as the amount (μg) of antibody that will stain a cell sample in a final volume of 100 μL.

T-bet Monoclonal antibody specifically detects T-bet in Human, Mouse, Rhesus Monkey samples. It is validated for Flow Cytometry.
Specifications

Specifications

T-bet
0.2 mg/mL
Monoclonal
Liquid
RUO
PBS with 0.09% sodium azide; pH 7.2
HGNC:11599; LOW QUALITY PROTEIN: T-box transcription factor TBX21; Tbet; T-bet; TBLYM; T-box 21; T-box expressed in T cells; T-box protein 21; T-box transcription factor 21; T-box transcription factor TBX21; TBT1; TBX21; T-cell-specific T-box transcription factor T-bet; T-PET; transcription factor TBLYM; transcription factor T-box 21
Tbx21
Primary
4° C, store in dark, DO NOT FREEZE!
Tbx21
eBio4B10 (4B10)
Flow Cytometry
PE-Cyanine7
Mouse
Human, Mouse, Rhesus Monkey
Q9JKD8, Q9UL17
30009, 57765, 694044
IgG1 κ
Affinity chromatography
Antibody
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