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T-bet Mouse anti-Human, Mouse, PE, Clone: 4B10, eBioscience™

Mouse Monoclonal Antibody

Brand:  Affymetrix eBioscience 12-5825-82

UNSPSC : 12352200

Code : Z2

Additional Details : Weight : 0.25000kg

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Product Code. 15238849

  • £242.50 / 100µg


EU Stock 15
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Disclaimers:

For Research Use Only.


Specifications

Description

The eBio4B10 monoclonal antibody reacts with mouse, rhesus moneky and human T-bet. T-bet is a Th1-specific T-box transcription factor critical to the development of the Th1 CD4+ T cell lineage. This is known based on the observations that T-Bet deficient mice have impaired Th1 cell development, and that ectopic expression of T-Bet results in development skewed to the Th1 lineage. T-Bet expression is induced by the Th1 cytokine IFN gamma, and T-Bet also regulates the expression of IFN gamma, likely, at least in part, through the modification of DNA accessibility and histone remodeling. In addition to IFN gamma, T-Bet is also known to regulate the expression of IL-12R beta and IL-2. Moreover, T-Bet plays a role in class-switch recombination in B-cells.
Description & Specifications

Specifications

T-bet
4-B10)
PE
aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Murine
100μg
Store at 2-8°C. Do not freeze. Light-sensitive material.
Monoclonal
Flow Cytometry (Intracellular Staining)
0.2mg/mL
Conjugated
Th1-specific T box transcription factor, T-box expressed in T cells
IgG1
RUO
Primary
Rhesus