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T-bet, clone: eBio4B10 (4B10), eBioscience™

Mouse Monoclonal Antibody

Brand:  Affymetrix eBioscience 14-5825-82

Code : Z2

Additional Details : Weight : 0.01000kg

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Product Code. 15227497

  • £130.26 / 100µg


EU Stock 3
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Description

Description

Description: The eBio4B10 monoclonal antibody reacts with mouse and human T-bet. T-bet is a Th1-specific T-box transcription factor critical to the development of the Th1 CD4+ T cell lineage. This is known based on the observations that T-Bet deficient mice have impaired Th1 cell development, and that ectopic expression of T-Bet results in development skewed to the Th1 lineage. T-Bet expression is induced by the Th1 cytokine IFN gamma, and T-Bet also regulates the expression of IFN gamma, likely, at least in part, through the modification of DNA accessibility and histone remodeling. In addition to IFN gamma, T-Bet is also known to regulate the expression of IL-12R beta and IL-2. Moreover, T-Bet plays a role in class-switch recombination in B-cells.Applications Reported: This eBio4B10 antibody has been reported for use in immunohistochemical staining of formalin-fixed paraffin embedded tissue sections (with citrate antigen retrieval), immunoprecipitation, and immunoblotting (WB).Applications Tested: This eBio4B10 antibody has been tested by western blot analysis of Th1-polarized mouse CD4+ T cells and can be used at 2μg/mL as a starting dilution for western blotting.Purity: Greater than 90%, as determined by SDS-PAGE.Aggregation: Less than 10%, as determined by HPLC.Filtration: 0.2μm post-manufacturing filtered.
Specifications

Specifications

T-bet
Monoclonal
0.5mg/mL
PBS with 0.09% sodium azide; pH 7.2
Q9JKD8, Q9UL17
T-PET, T-bet, TBET, TBLYM, T-box expressed in T cells, T-box protein 21, T-box transcription factor TBX21, T-cell-specific T-box transcription factor T-bet, transcription factor TBLYM
Murine
Affinity chromatography
RUO
Antibody
Monoclonal
Rhesus
Western Blot
4-B10), eBio4B10 (4B10
Unconjugated
TBX21
Purified
Tbx21
IgG1, kappa
100μg
Store at 2-8°C.
Primary
30009
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