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T-bet Mouse anti-Human, Mouse, Clone: 4B10, eBioscience™

Mouse Monoclonal Antibody

Brand:  Affymetrix eBioscience 14-5825-80

UNSPSC : 12352200

Code : Z2

Additional Details : Weight : 0.01000kg

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Product Code. 15217497

  • £60.53 / 25µg


Estimated Shipment
01-11-2017
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Disclaimers:

For Research Use Only.


Description

Description

The eBio4B10 monoclonal antibody reacts with mouse and human T-bet. T-bet is a Th1-specific T-box transcription factor critical to the development of the Th1 CD4+ T cell lineage. This is known based on the observations that T-Bet deficient mice have impaired Th1 cell development, and that ectopic expression of T-Bet results in development skewed to the Th1 lineage. T-Bet expression is induced by the Th1 cytokine IFN gamma, and T-Bet also regulates the expression of IFN gamma, likely, at least in part, through the modification of DNA accessibility and histone remodeling. In addition to IFN gamma, T-Bet is also known to regulate the expression of IL-12R beta and IL-2. Moreover, T-Bet plays a role in class-switch recombination in B-cells.
Specifications

Specifications

T-bet
4-B10)
Unconjugated
Purified
Murine
25μg
Store at 2-8°C.
Monoclonal
Western Blot
0.5mg/mL
aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Th1-specific T box transcription factor, T-box expressed in T cells
IgG1
RUO
Primary
Rhesus