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T 0901317, Tocris Bioscience™

Potent liver X receptor (LXR) agonist; also CAR inverse agonist

Brand:  Tocris (Bio-Techne) 237350

Code : Z1

Additional Details : Weight : 0.01000kg

Quantity 50mg

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Product Code. 13461104

  • £340.00 / 50mg


Estimated Shipment
02-07-2018
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Description

Description

Potent, high affinity liver X receptor (LXR) agonist (EC50 ∽ 50 nM, Kd values are 7 and 22 nM for LXR-α and LXR-β respectively). Upregulates expression of the ABCA1 gene associated with cholesterol efflux regulation and HDL metabolism. Decreases amyloid-β production in primary neurons in vitro. Displays an EC50 of ∽ 5 μM for activation of bile acid farnesoid X receptors (FXRs); 10-fold more potent than natural FXR ligand chenodeoxycholic acid. Also exhibits inverse agonist activity at constitutive androstane receptors (CAR).
Specifications

Chemical Identifiers

T 0901317
C17H12F9NO3S
481.33
N-(2,2,2-Trifluoroethyl)-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]benzenesulfonamide

Specifications

T 0901317
293754-55-9
C17H12F9NO3S
N-(2,2,2-Trifluoroethyl)-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]benzenesulfonamide
50mg
>98%
481.33
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