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T 0156 hydrochloride, Tocris Bioscience™

Highly potent, selective PDE5 inhibitor

Brand:  Tocris (Bio-Techne) 167610

Code : Z1

Additional Details : Weight : 0.01000kg

Quantity 10mg

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Product Code. 13439903

  • £189.63 / 10mg

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Description

Description

Potent and selective inhibitor of phosphodiesterase type 5 (PDE5); more selective than sildenafil (IC50 values are 0.23, 56 and > 63000 nM for T 0156 and 3.6, 29 and > 270 nM for sildenafil at PDE5, PDE6 and PDEs 1 - 4 respectively). Selective over 30 other enzymes and receptors (IC50 > 10 mM) and potentiates electrical field stimulation-induced relaxation of isolated rabbit corpus cavernosum. Active in vivo.
Specifications

Chemical Identifiers

324572-93-2
620.059
1,2-dihydro-2-2-methyl-4-pyridinyl methyl-1-oxo-8-2-pyrimidinylmethoxy-4-3,4,5-trimethoxyphenyl-2,7-naphthyridine-3-carboxylic acid methyl ester hydrochloride, t 0156 hydrochloride, 2-2-methylpyridin-4-yl methyl-4-3,4,5-trimethoxyphenyl-8-pyrimidin-2-yl methoxy-1,2-dihydro-1-oxo-2,7-naphthyridine-3-carboxylic acid methyl ester hydrochloride
methyl 2-[(2-methylpyridin-4-yl)methyl]-1-oxo-8-(pyrimidin-2-ylmethoxy)-4-(3,4,5-trimethoxyphenyl)-2,7-naphthyridine-3-carboxylate;hydrochloride
C31H30ClN5O7
RBJCBXAXUHCWBR-UHFFFAOYSA-N
9852041
CC1=NC=CC(=C1)CN2C(=C(C3=C(C2=O)C(=NC=C3)OCC4=NC=CC=N4)C5=CC(=C(C(=C5)OC)OC)OC)C(=O)OC.Cl

Specifications

10mg
324572-93-2
1,2-dihydro-2-2-methyl-4-pyridinyl methyl-1-oxo-8-2-pyrimidinylmethoxy-4-3,4,5-trimethoxyphenyl-2,7-naphthyridine-3-carboxylic acid methyl ester hydrochloride, t 0156 hydrochloride, 2-2-methylpyridin-4-yl methyl-4-3,4,5-trimethoxyphenyl-8-pyrimidin-2-yl methoxy-1,2-dihydro-1-oxo-2,7-naphthyridine-3-carboxylic acid methyl ester hydrochloride
CC1=NC=CC(=C1)CN2C(=C(C3=C(C2=O)C(=NC=C3)OCC4=NC=CC=N4)C5=CC(=C(C(=C5)OC)OC)OC)C(=O)OC.Cl
620.059
620.06
T 0156 hydrochloride
C31H30ClN5O7
RBJCBXAXUHCWBR-UHFFFAOYSA-N
methyl 2-[(2-methylpyridin-4-yl)methyl]-1-oxo-8-(pyrimidin-2-ylmethoxy)-4-(3,4,5-trimethoxyphenyl)-2,7-naphthyridine-3-carboxylate;hydrochloride
9852041
>99%
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