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Syk, clone: 4D10.1, eBioscience™

Mouse Monoclonal Antibody

Brand:  Affymetrix eBioscience 14-6696-82

Code : Z2

Additional Details : Weight : 0.01000kg

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Product Code. 15227937

  • £168.82 / 100µg


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Disclaimers:

For Research Use Only.


Description

Description

Description: This 4D10.1 monoclonal antibody recognizes human Syk, a 72-kDa member of the Syk/ZAP-70 family of non-receptor protein tyrosine kinases. Syk is expressed most highly in B cells, with lower expression in immature thymocytes, mast cells, and platelets. Syk can also be detected in fibroblasts, epithelial cells, hepatocytes, endothelial cells, and neuronal cells. This protein is a major component of signaling cascades downstream of the B and T cell antigen receptors and plays an essential role in lymphocyte development. Upon recruitment to immunoreceptor tyrosine-based activation motifs (ITAMs) on the antigen receptors, Syk is activated by phosphorylation on multiple tyrosines. Once activated, Syk phosphorylates proteins such as phospholipase C gamma and BLNK/SLP-65. Finally, abnormal Syk expression has been linked to tumor cell migration and invasion in several cancers.Applications Reported: This 4D10.1 antibody has been reported for use in flow cytometric analysis and western blotting.Applications Tested: This 4D10.1 antibody has been tested by immunoblotting of reduced Ramos cell lysate. This can be used at less than or equal to 5 ug/mL. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest.Purity: Greater than 90%, as determined by SDS-PAGE.Aggregation: Less than 10%, as determined by HPLC.Filtration: 0.2μm post-manufacturing filtered.
Specifications

Specifications

Syk
4D10.1
Unconjugated
Purified
IgG2a
RUO
Primary
Human
Western Blot
0.5mg/mL
aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Murine
100μg
Store at 2-8°C.
Monoclonal
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