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Syk Mouse anti-Human, APC, Clone: 4D10.1, eBioscience™

Mouse Monoclonal Antibody

Brand:  Affymetrix eBioscience 17-6696-42

Code : NEW

Additional Details : Weight : 0.23750kg

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Product Code. 15558176

  • £180.20 / 100 tests


EU Stock 6
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Disclaimers:

For Research Use Only.


Specifications

Description

This 4D10.1 monoclonal antibody recognizes human Syk, a 72kDa member of the Syk/ZAP-70 family of non-receptor protein tyrosine kinases. Syk is expressed most highly in B cells, with lower expression in immature thymocytes, mast cells, and platelets. Syk can also be detected in fibroblasts, epithelial cells, hepatocytes, endothelial cells, and neuronal cells. This protein is a major component of signaling cascades downstream of the B and T cell antigen receptors and plays an essential role in lymphocyte development. Upon recruitment to immunoreceptor tyrosine-based activation motifs (ITAMs) on the antigen receptors, Syk is activated by phosphorylation on multiple tyrosines. Once activated, Syk phosphorylates proteins such as phospholipase C gamma and BLNK/SLP-65. Finally, abnormal Syk expression has been linked to tumor cell migration and invasion in several cancers.
Description & Specifications

Specifications

Syk
4D10.1
Allophycocyanin
Conjugated
IgG2a
RUO
Primary
Human
Flow Cytometry (Intracellular Staining)
5μL (0.125μg)/test
aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Murine
100 Tests
Store at 2-8°C. Do not freeze. Light-sensitive material.
Monoclonal