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Syk Mouse anti-Human, APC, Clone: 4D10.1, eBioscience™

Mouse Monoclonal Antibody

Brand:  Affymetrix eBioscience 17-6696-42

Code : NEW

Additional Details : Weight : 0.23750kg

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Product Code. 15558176

  • £180.20 / 100 tests


EU Stock 6
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Disclaimers:

For Research Use Only.


Description

Description

This 4D10.1 monoclonal antibody recognizes human Syk, a 72kDa member of the Syk/ZAP-70 family of non-receptor protein tyrosine kinases. Syk is expressed most highly in B cells, with lower expression in immature thymocytes, mast cells, and platelets. Syk can also be detected in fibroblasts, epithelial cells, hepatocytes, endothelial cells, and neuronal cells. This protein is a major component of signaling cascades downstream of the B and T cell antigen receptors and plays an essential role in lymphocyte development. Upon recruitment to immunoreceptor tyrosine-based activation motifs (ITAMs) on the antigen receptors, Syk is activated by phosphorylation on multiple tyrosines. Once activated, Syk phosphorylates proteins such as phospholipase C gamma and BLNK/SLP-65. Finally, abnormal Syk expression has been linked to tumor cell migration and invasion in several cancers.
Specifications

Specifications

Syk
4D10.1
Allophycocyanin
Conjugated
IgG2a
RUO
Primary
Human
Flow Cytometry (Intracellular Staining)
5μL (0.125μg)/test
aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Murine
100 Tests
Store at 2-8°C. Do not freeze. Light-sensitive material.
Monoclonal