Survivin (BIRC5) Mouse anti-Human, PE, Clone: STLALYV, eBioscience™

Mouse Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 12-9176-42

Code: NEW

Additional Details:
Additional Details: Weight: 0.23750kg



Disclaimers: For Research Use Only.

Product Code. 15517186

Quantity Price
1 £ 225.61 / 100 tests
Estimated Shipment date
from Supplier 04-05-2017
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Description and Specification

Specification

Regulatory Status RUO
Monoclonal or Polyclonal Monoclonal
Format Conjugated
Host Species Mouse
Species Reactivity Human
Primary or Secondary Primary
Antigen Survivin (BIRC5)
Isotype IgG2b
Applications Flow Cytometry (Intracellular Staining)
Concentration 5μL (0.5μg)/test
Clone STLALYV
Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material.
Gene Alias Birc5
Quantity 100 tests
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Conjugate PE

This STLALYV monoclonal antibody recognizes human survivin (also known as Birc5). Survivin is a member of the inhibitor of apoptosis (IAP) family that also includes XIAP, c-IAP1, c-IAP2, and NAIP. Survivin functions to inhibit caspase activation, thereby leading to negative regulation of apoptosis. Survivin also plays a critical role in mitosis and cytokinesis where it is expressed only during G2/M and localizes to the mitotic spindle and is found at the cleavage furrow/midplate. Thus, survivin is highly expressed in tumors and in fetal tissue, but is absent in terminally-differentiated cells and non-proliferating cells. Deletion of survivin in developing thymocytes as well as in mature T cells showed that survivin is critical for cell division in lymphoid cells but not for inhibition of survival; the same is true for B lymphocytes.