Survivin (BIRC5) Mouse anti-Human, Clone: STLALYV, eBioscience™

Mouse Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 14-9176-80

Code: NEW

Additional Details:
Additional Details: Weight: 0.09500kg



Disclaimers: For Research Use Only.

Product Code. 15587586

Quantity Price
1 £ 80.62 / 25µg
Estimated Shipment date
from Supplier 04-05-2017
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Description and Specification

Specification

Conjugate Unlabeled
Monoclonal or Polyclonal Monoclonal
Storage Requirements Store at 2-8°C.
Host Species Mouse
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Applications Immunocytochemistry
Applications Immunohistochemistry (Formalin/Paraffin)
Applications Microscopy
Isotype IgG2b
Quantity 25μg
Concentration 0.5mg/mL
Antigen Survivin (BIRC5)
Gene Alias Birc5
Species Reactivity Human
Format Purified
Regulatory Status RUO
Clone STLALYV
Primary or Secondary Primary

This STLALYV monoclonal antibody recognizes human survivin (also known as Birc5). Survivin is a member of the inhibitor of apoptosis (IAP) family that also includes XIAP, c-IAP1, c-IAP2, and NAIP. Survivin functions to inhibit caspase activation, thereby leading to negative regulation of apoptosis. Survivin also plays a critical role in mitosis and cytokinesis where it is expressed only during G2/M and localizes to the mitotic spindle and is found at the cleavage furrow/midplate. Thus, survivin is highly expressed in tumors and in fetal tissue, but is absent in terminally-differentiated cells and non-proliferating cells. Deletion of survivin in developing thymocytes as well as in mature T cells showed that survivin is critical for cell division in lymphoid cells but not for inhibition of survival; the same is true for B lymphocytes.