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Survivin, clone: STLALYV, eBioscience™

Mouse Monoclonal Antibody

Brand:  Affymetrix eBioscience 14-9176-80

Code : NEW

Additional Details : Weight : 0.09500kg

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Product Code. 15587586

  • £83.79 / 25µg


Estimated Shipment date
from Supplier 01-06-2018
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Description

Description

Description: This STLALYV monoclonal antibody recognizes human survivin (also known as Birc5). Survivin is a member of the inhibitor of apoptosis (IAP) family that also includes XIAP, c-IAP1, c-IAP2, and NAIP. Survivin functions to inhibit caspase activation, thereby leading to negative regulation of apoptosis. Survivin also plays a critical role in mitosis and cytokinesis where it is expressed only during G2/M and localizes to the mitotic spindle and is found at the cleavage furrow/midplate. Thus, survivin is highly expressed in tumors and in fetal tissue, but is absent in terminally-differentiated cells and non-proliferating cells. Deletion of survivin in developing thymocytes as well as in mature T cells showed that survivin is critical for cell division in lymphoid cells but not for inhibition of survival; the same is true for B lymphocytes.Applications Reported: This STLALYV antibody has been reported for use in immunohistochemical staining of formalin-fixed paraffin embedded tissue sections, microscopy, and immunocytochemistry. (Fluorochrome-conjugated STLALYV is recommended for use in intracellular flow cytometry.).Applications Tested: This STLALYV antibody has been tested by immunocytochemistry of formaldehyde-fixed and permeabilized cells and can be used at less than or equal to 5 μg/mL. This STLALYV antibody has also been tested by immunohistochemistry of formalin-fixed paraffin embedded tissue using high pH antigen retrieval and can be used at less than or equal to 5 μg/mL. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest.Purity: Greater than 90%, as determined by SDS-PAGE.Aggregation: Less than 10%, as determined by HPLC.Filtration: 0.2μm post-manufacturing filtered.
Specifications

Specifications

Survivin (BIRC5)
Monoclonal
0.5mg/mL
PBS with 0.09% sodium azide; pH 7.2
O15392
API4, Apoptosis Inhibitor 4, Apoptosis inhibitor survivin, Baculoviral IAP repeat containing 5, BIRC 5, EPR 1, IAP4, SVV, TIAP
Murine
Affinity chromatography
RUO
Antibody
Monoclonal
Human
Microscopy
STLALYV
Unconjugated
BIRC5
Purified
BIRC5
IgG2b, kappa
25μg
Store at 2-8°C.
Primary
332
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