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Survivin, Alexa Fluor 488, clone: STLALYV, eBioscience™

Mouse Monoclonal Antibody

Brand:  Affymetrix eBioscience 53-9176-80

Code : NEW

Additional Details : Weight : 0.09500kg

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Product Code. 15550267

  • £109.08 / 25µg


Estimated Shipment date
from Supplier 27-06-2018
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Description

Description

Description: This STLALYV monoclonal antibody recognizes human survivin (also known as Birc5). Survivin is a member of the inhibitor of apoptosis (IAP) family that also includes XIAP, c-IAP1, c-IAP2, and NAIP. Survivin functions to inhibit caspase activation, thereby leading to negative regulation of apoptosis. Survivin also plays a critical role in mitosis and cytokinesis where it is expressed only during G2/M and localizes to the mitotic spindle and is found at the cleavage furrow/midplate. Thus, survivin is highly expressed in tumors and in fetal tissue, but is absent in terminally-differentiated cells and non-proliferating cells. Deletion of survivin in developing thymocytes as well as in mature T cells showed that survivin is critical for cell division in lymphoid cells but not for inhibition of survival; the same is true for B lymphocytes.Applications Reported: This STLALYV antibody has been reported for use in microscopy, and immunocytochemistry.Applications Tested: This STLALYV antibody has been tested by immunocytochemistry of fixed and permeabilized cells and can be used at less than or equal to 10 μg/mL. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest.Excitation: 488 nm; Emission: 519 nm; Laser: Blue Laser.Filtration: 0.2μm post-manufacturing filtered.
Specifications

Specifications

Survivin (BIRC5)
Monoclonal
0.5mg/mL
PBS with 0.1% gelatin and 0.09% sodium azide; pH 7.2
O15392
API4, Apoptosis Inhibitor 4, Apoptosis inhibitor survivin, Baculoviral IAP repeat containing 5, BIRC 5, EPR 1, IAP4, SVV, TIAP
Murine
Affinity chromatography
RUO
Antibody
Monoclonal
Human
Microscopy
STLALYV
Alexa Fluor 488
BIRC5
Conjugated
BIRC5
IgG2b, kappa
25μg
Store at 2-8°C. Do not freeze. Light-sensitive material.
Primary
332
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