Sox 10 Mouse, Clone: 20B7, eBioscience™

Mouse Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 14-5923-80

Code: NEW

Additional Details:
Additional Details: Weight: 0.09500kg



Disclaimers: For Research Use Only.

Product Code. 15577456

Quantity Price
1 £ 73.93 / 25µg
Estimated Shipment date
from Supplier 03-05-2017
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Description and Specification

Specification

Regulatory Status RUO
Host Species Mouse
Clone 20B7
Applications Immunocytochemistry
Applications Immunohistochemistry (Formalin/Paraffin)
Applications Immunohistochemistry (Frozen)
Applications Microscopy
Format Purified
Antigen Sox 10
Isotype IgG1
Primary or Secondary Primary
Quantity 25μg
Conjugate Unlabeled
Concentration 0.5mg/mL
Species Reactivity Human, Mouse, Rat
Monoclonal or Polyclonal Monoclonal
Gene Alias SRY-Related HMG-Box Gene 10
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Storage Requirements Store at 2-8°C.

The monoclonal antibody 20B7 recognizes Sox10, is a member of the Sox superfamily (SRY-related HMG-box) that contain a DNA binding domain (high-mobility group domain) and functions as a transcription factor. Initially, Sox10 expression is localized to the developing neural crest and peripheral nervous system, but later is expressed in glial progenitors and mature oligodendrocytes. Sox10 is involved in stem cell maintenance, melanocyte differentiation, as well as central and peripheral gliogenesis and neurogenesis. Sox10 regulation of downstream proteins such as MASH1, PHOX2B, PDGF-alpha, and MITF is dependent on expression level. Sox10 is also expressed in multipotent vascular stem cells, melanomas, and gliomas.

The 20B7 antibody is reported to recognize human and rat Sox 10, and based on homology should recognize mouse Sox10.