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SNS 032, Tocris Bioscience™

Cdk inhibitor; potently inhibits cdk2, cdk7 and cdk9

Brand:  Tocris (Bio-Techne) 407510

Code : Z1

Additional Details : Weight : 0.01000kg

Quantity 10mg

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Product Code. 13434084

  • £235.20 / 10mg

Estimated Shipment date
from Supplier 21-11-2019

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Description

Description

Cyclin dependent kinase (cdk) inhibitor (reported IC50 values are 0.004 - 0.048, 0.0045 - 0.05, 0.062 - 0.29, 0.2-0.48, 0.4 and 0.45 μM for cdk9, cdk2, cdk7, cdk1, cdk5 and cdk4, respectively). Displays no activity against 190 additional kinases (IC50 >1 μM). Arrests the cell cycle at G2/M; inhibits transcription, proliferation and colony formation, and induces apoptosis in RPMI-8226 multiple myeloma cells. Prevents tumor cell-induced VEGF secretion and in vitro angiogenesis.
Specifications

Chemical Identifiers

345627-80-7
380.525
n-5-5-tert-butyl oxazol-2-yl methyl thio thiazol-2-yl piperidine-4-carboxamide, n-5-5-tert-butyl-1,3-oxazol-2-yl methylsulfanyl-1,3-thiazol-2-yl piperidine-4-carboxamide, n-5-5-tert-butyl-1,3-oxazol-2-yl methyl sulfanyl-1,3-thiazol-2-yl piperidine-4-carboxamide, n-5-5-1,1-dimethylethyl-2-oxazolyl methyl thio-2-thiazolyl-4-piperidinecarboxamide, 4-piperidinecarboxamide, n-5-5-1,1-dimethylethyl-2-oxazolyl methyl thio-2-thiazolyl, kinome_3820, pubchem16670, tube004
N-[5-[(5-tert-butyl-1,3-oxazol-2-yl)methylsulfanyl]-1,3-thiazol-2-yl]piperidine-4-carboxamide
C17H24N4O2S2
OUSFTKFNBAZUKL-UHFFFAOYSA-N
3025986
CC(C)(C)C1=CN=C(O1)CSC2=CN=C(S2)NC(=O)C3CCNCC3

Specifications

10mg
345627-80-7
n-5-5-tert-butyl oxazol-2-yl methyl thio thiazol-2-yl piperidine-4-carboxamide, n-5-5-tert-butyl-1,3-oxazol-2-yl methylsulfanyl-1,3-thiazol-2-yl piperidine-4-carboxamide, n-5-5-tert-butyl-1,3-oxazol-2-yl methyl sulfanyl-1,3-thiazol-2-yl piperidine-4-carboxamide, n-5-5-1,1-dimethylethyl-2-oxazolyl methyl thio-2-thiazolyl-4-piperidinecarboxamide, 4-piperidinecarboxamide, n-5-5-1,1-dimethylethyl-2-oxazolyl methyl thio-2-thiazolyl, kinome_3820, pubchem16670, tube004
CC(C)(C)C1=CN=C(O1)CSC2=CN=C(S2)NC(=O)C3CCNCC3
380.525
380.53
SNS 032
C17H24N4O2S2
OUSFTKFNBAZUKL-UHFFFAOYSA-N
N-[5-[(5-tert-butyl-1,3-oxazol-2-yl)methylsulfanyl]-1,3-thiazol-2-yl]piperidine-4-carboxamide
3025986
>99%
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