Snail Mouse anti-Human, Clone: 20C8, eBioscience™

Mouse Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 14-9859-82

Code: NEW

Additional Details:
Additional Details: Weight: 0.09500kg



Disclaimers: For Research Use Only.

Product Code. 15547696

Quantity Price
1 £ 142.93 / 100µg
EU Stock 1
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Description and Specification

Specification

Applications Enzyme Linked Immunosorbent Assay
Applications Immunocytochemistry
Applications Immunohistochemistry (Formalin/Paraffin)
Applications Immunoprecipitation
Applications Western Blotting
Monoclonal or Polyclonal Monoclonal
Primary or Secondary Primary
Species Reactivity Human
Isotype IgG2a
Quantity 100μg
Regulatory Status RUO
Format Purified
Clone 20C8
Antigen Snail
Host Species Mouse
Storage Requirements Store at 2-8°C.
Concentration 0.5mg/mL
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Conjugate Unlabeled

The monoclonal antibody 20C8 recognizes human Snail1, a 29kDa zinc finger transcription factor. Snail1 and Slug both belong to a family of transcription factors that are responsible for inducing epithelial to mesenchymal transition (EMT) during normal organ development and tumor progression. Snail1 expression is localized to both the cytoplasm and nucleus and functions as a transcriptional repressor of E-cadherin, claudins, occludin, and desmoplakin. During embryonic development, Snail1 is localized to the mesoderm, while in the adult, expression is inducible and is usually limited to activated fibroblasts and some mesenchymal cells. Overexpression of Snail1 has been found in carcinomas and fibrosarcomas and may be used as an early marker for EMT.