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Snail1, clone: 20C8, eBioscience™

Mouse Monoclonal Antibody

Brand:  Affymetrix eBioscience 14-9859-82

Code : NEW

Additional Details : Weight : 0.09500kg

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Product Code. 15547696

  • £146.05 / 100µg


EU Stock 1
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Description

Description

Description: The monoclonal antibody 20C8 recognizes human Snail1, a 29kDa zinc finger transcription factor. Snail1 and Slug both belong to a family of transcription factors that are responsible for inducing epithelial to mesenchymal transition (EMT) during normal organ development and tumor progression. Snail1 expression is localized to both the cytoplasm and nucleus and functions as a transcriptional repressor of E-cadherin, claudins, occludin, and desmoplakin. During embryonic development, Snail1 is localized to the mesoderm, while in the adult, expression is inducible and is usually limited to activated fibroblasts and some mesenchymal cells. Overexpression of Snail1 has been found in carcinomas and fibrosarcomas and may be used as an early marker for EMT.Applications Reported: This 20C8 antibody has been reported for use in immunohistochemical staining of formalin-fixed paraffin embedded (IHC-P) tissue, ELISA, immunoprecipitation, western blotting, and immunocytochemistry.Applications Tested: This 20C8 antibody has been tested by immunohistochemistry on formalin-fixed paraffin embedded (FFPE) human breast cancer tissue using low pH antigen retrieval. The antibody can also be used following high pH antigen retrieval. This antibody can be used at less than or equal to 5 ug/mL. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest.Purity: Greater than 90%, as determined by SDS-PAGE.Aggregation: Less than 10%, as determined by HPLC.Filtration: 0.2μm post-manufacturing filtered.
Specifications

Specifications

Snail
Monoclonal
0.5mg/mL
PBS with 0.09% sodium azide; pH 7.2
O95863
Zinc finger protein SNAI1, Snail protein homolog, Sna protein
Murine
Affinity chromatography
RUO
Antibody
Monoclonal
Human
ELISAþImmunocytochemistryþImmunohistochemistryþImmunoprecipitationþWestern Blot
20C8
Unconjugated
SNAI1
Purified
SNAI1
IgG2a, kappa
100μg
Store at 2-8°C.
Primary
6615
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