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SN 38, Tocris Bioscience™

DNA topoisomerase I inhibitor; antitumor

Brand:  Tocris (Bio-Techne) 268450

Code : Z1

Additional Details : Weight : 0.01000kg

Quantity 50mg

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Product Code. 13441724

  • £461.58 / 50mg

Estimated Shipment date
from Supplier 19-11-2019

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Description

Description

Active metabolite of CPT-11 (Cat. No. 2688) that inhibits DNA topoisomerase I (IC50 values are 0.74 and 1.9 μM in P388 and Ehrlich cells respectively). Inhibits DNA and RNA synthesis (IC50 values are 0.077 and 1.3 μM respectively) but does not affect protein synthesis. Displays potent antitumor activity against a range of human tumor cell lines (IC50 values are 3.3, 13, 19 and 22 nM for HCT-116, BEL-7402, HL60 and HELA cells respectively).
Specifications

Chemical Identifiers

86639-52-3
392.411
7-ethyl-10-hydroxycamptothecin, sn 38 lactone, 7-ethyl-10-hydroxy-camptothecin, 10-hydroxy-7-ethylcamptothecin, 7-ethyl-10-hydroxycamptothecine, le-sn38, 7-ethyl-10-hydroxy-20 s-camptothecin, captothecin, 7-ethyl-10-hydroxy, s-4,11-diethyl-4,9-dihydroxy-1h-pyrano 3',4':6,7 indolizino 1,2-b quinoline-3,14 4h,12h-dione, 7-ethyl-10-hydroxy camptothecin
CHEBI:8988
C22H20N2O5
FJHBVJOVLFPMQE-QFIPXVFZSA-N
104842
CCC1=C2C=C(C=CC2=NC3=C1CN4C3=CC5=C(C4=O)COC(=O)C5(CC)O)O

Specifications

50mg
86639-52-3
7-ethyl-10-hydroxycamptothecin, sn 38 lactone, 7-ethyl-10-hydroxy-camptothecin, 10-hydroxy-7-ethylcamptothecin, 7-ethyl-10-hydroxycamptothecine, le-sn38, 7-ethyl-10-hydroxy-20 s-camptothecin, captothecin, 7-ethyl-10-hydroxy, s-4,11-diethyl-4,9-dihydroxy-1h-pyrano 3',4':6,7 indolizino 1,2-b quinoline-3,14 4h,12h-dione, 7-ethyl-10-hydroxy camptothecin
CCC1=C2C=C(C=CC2=NC3=C1CN4C3=CC5=C(C4=O)COC(=O)C5(CC)O)O
104842
392.4
SN 38
C22H20N2O5
FJHBVJOVLFPMQE-QFIPXVFZSA-N
392.411
CHEBI:8988
>98%
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