missing translation for 'onlineSavingsMsg'
Learn More

Thermo Scientific™ SM(PEG)4 (PEGylated SMCC crosslinker)

Crosslink amines to sulfhydryls with these crosslinkers containing NHS-ester and maleimide groups at ends of water-soluble polyethylene glycol spacer arms (17.6 to 95.2A).

£341.00 - £1206.00

Specifications

Chemical Reactivity Amine-Sulfhydryl
Cleavable No
Description SM(PEG)4
Molecular Weight (g/mol) 513.5
PEGylated Yes
View More Specs

Products 2
Product Code Brand Description Quantity Price Quantity & Availability  
Product Code Brand Description Quantity Price Quantity & Availability  
10711185
View Documents Promotion Details
Thermo Scientific™
22107
SM(PEG)4 1 g
£1206.00
1g
View alternative products
Save Up to 
»
Estimated Shipment: 11-04-2024
to see stock.
Please to purchase this item. Need a web account? Register with us today!
11851265
View Documents Promotion Details
Thermo Scientific™
22104
SM(PEG)4 100 mg
£341.00
100mg
View alternative products
Save Up to 
»
Estimated Shipment: 08-04-2024
to see stock.
Add to basket
 
Description

Description

Thermo Scientific™ Pierce SM(PEG)n is a series of amine-to-sulfhydryl crosslinkers that differ in length from 17.6 to 95.2 Ås as a result of polyethylene glycol spacer arms containing n equals 2 to 24 ethylene glycol units.

The SM(PEG)n reagents are six crosslinkers that have identical amine- and sulfhydryl-reactive groups but differ in length as a result of spacer arms composed of different numbers of ethylene glycol units. Their structures (shown below) have the form NHS-(PEG)n-Maleimide, where n represents 2, 4, 6, 8, 12 or 24 polyethylene glycol (PEG) units. Each SM(PEG)n reagent is produced at the specified length without contamination from analogs of other lengths.The availability of this set of reagents makes it possible to optimize crosslinking experiments to obtain the best conjugate efficiency and function for the intended application or analysis method. Considered together with AMAS (Part No. 22295) and the popular SMCC (Part No. 22360), these reagents allow for amine-to-sulfhydryl crosslinking across spaces ranging from 4.4 to 95.2Å. In addition, the hydrophilic PEG content of SM(PEG)n reagents adds to the aqueous solubility of these crosslinkers and their conjugates. PEG is also less immunogenic than other types of crosslinker spacers, making these reagents ideal for immunogen preparation.

Highlights:

  • Homologous series of increasing spacer arm length, ideal for optimizing conjugation of protein interactions
  • Water-soluble polyethylene glycol (PEG) spacer arms help to maintain or increase solubility of crosslinked proteins
  • Reagents readily dissolve in DMSO for subsequent dilution in aqueous reaction buffers
  • Reactive groups: NHS ester and maleimide
  • Reactive toward: amino and sulfhydryl groups

NHS-PEG2-Maleimide

  • Two ethylene oxide subunits
  • Alternate names: Mal-dPEG2-NHS, NHS-PEG2-Maleimide
  • Molecular formula C18H23N3O9
  • Spacer arm length 17.6Å
  • Mass added to target per crosslink 310.12
  • MW 425.39

NHS-PEG4-Maleimide

  • Four ethylene oxide subunits
  • Alternate names Mal-dPEG4-NHS, NHS-PEG4-Maleimide
  • Molecular formula C22H31N3O11
  • Spacer arm length 24.6Å
  • Mass added to target per crosslink 398.17
  • MW 513.50

NHS-PEG6-Maleimide

  • Six ethylene oxide subunits
  • Alternate names Mal-dPEG6-NHS, NHS-PEG6-Maleimide
  • Molecular formula C26H39N3O13
  • Spacer arm length 32.25Å
  • Mass added to target per crosslink 486.20
  • MW 601.60

NHS-PEG8-Maleimide

  • Eight ethylene oxide subunits
  • Alternate names Mal-dPEG8-NHS, NHS-PEG8-Maleimide
  • Molecular formula C30H47N3O15
  • Spacer arm length 39.2Å
  • Mass added to target per crosslink 574.27
  • MW 689.71

NHS-PEG12-Maleimide

  • 12 ethylene oxide subunits Mal-dPEG12-NHS, NHS-PEG12-Maleimide
  • Molecular Formula C38H63N3O19
  • Spacer arm length 53.4Å
  • Mass added to target per crosslink 750.38
  • MW 865.92
Specifications

Specifications

Amine-Sulfhydryl
SM(PEG)4
Yes
Upon receipt store desiccated at -20°C.
Ambient
Chemical Labeling
Maleimide, NHS Ester
Solid
Standard
Crosslinker
No
513.5
24.6 Å
No
Pierce™
Heterobifunctional
Medium (10 to 30 Å)
Water
Yes
Videos
SDS
Documents

Documents

Product Certifications

For Research Use Only. Not for use in diagnostic procedures.