SAP (SLAM-Associated Protein) Rat anti-Human, PE, Clone: XLP-1D12, eBioscience™
Rat Monoclonal Antibody
Brand: Affymetrix eBioscience 12-9787-42
Code : NEW
Additional Details : Weight : 0.23750kg
DescriptionPlease refer to Best Protocols: Protocol B: One step protocol for (nuclear) intracellular proteins located under the Resources tab online. This can be used at 5 µL (0.5 µg) per test. A test is defined as the amount (µg) of antibody that will stain a cell sample in a final volume of 100 µL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. Excitation: 488-561 nm; Emission: 578 nm; Laser: Blue Laser, Green Laser, Yellow-Green Laser. Filtration: 0.2 μm post-manufacturing filtered. This gene encodes a protein that plays a major role in the bidirectional stimulation of T and B cells. This protein contains an SH2 domain and a short tail. It associates with the signaling lymphocyte-activation molecule, thereby acting as an inhibitor of this transmembrane protein by blocking the recruitment of the SH2-domain-containing signal-transduction molecule SHP-2 to its docking site. This protein can also bind to other related surface molecules that are expressed on activated T, B and NK cells, thereby modifying signal transduction pathways in these cells. Mutations in this gene cause lymphoproliferative syndrome X-linked type 1 or Duncan disease, a rare immunodeficiency characterized by extreme susceptibility to infection with Epstein-Barr virus, with symptoms including severe mononucleosis and maligt lymphoma. Multiple transcript variants encoding different isoforms have been found for this gene.
|SAP (SLAM-Associated Protein)|
|PBS with 0.1% gelatin, 0.2% BSA and 0.09% sodium azide; pH 7.2|
|DSHP, EBVS, IMD5, LYP, MTCP1, SH2D1A, XLP, XLPD|
|4° C, store in dark, DO NOT FREEZE!|
For Research Use Only.