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SAP (SLAM-Associated Protein) Rat anti-Human, PE, Clone: XLP-1D12, eBioscience™

Rat Monoclonal Antibody

Brand:  Affymetrix eBioscience 12-9787-42

Code : NEW

Additional Details : Weight : 0.23750kg

 View more versions of this product

Product Code. 15597226

  • £229.00 / 100 tests

EU Stock 1

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Description

Description

Please refer to Best Protocols: Protocol B: One step protocol for (nuclear) intracellular proteins located under the Resources tab online. This can be used at 5 µL (0.5 µg) per test. A test is defined as the amount (µg) of antibody that will stain a cell sample in a final volume of 100 µL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. Excitation: 488-561 nm; Emission: 578 nm; Laser: Blue Laser, Green Laser, Yellow-Green Laser. Filtration: 0.2 μm post-manufacturing filtered. This gene encodes a protein that plays a major role in the bidirectional stimulation of T and B cells. This protein contains an SH2 domain and a short tail. It associates with the signaling lymphocyte-activation molecule, thereby acting as an inhibitor of this transmembrane protein by blocking the recruitment of the SH2-domain-containing signal-transduction molecule SHP-2 to its docking site. This protein can also bind to other related surface molecules that are expressed on activated T, B and NK cells, thereby modifying signal transduction pathways in these cells. Mutations in this gene cause lymphoproliferative syndrome X-linked type 1 or Duncan disease, a rare immunodeficiency characterized by extreme susceptibility to infection with Epstein-Barr virus, with symptoms including severe mononucleosis and maligt lymphoma. Multiple transcript variants encoding different isoforms have been found for this gene.
Specifications

Specifications

SAP (SLAM-Associated Protein)
Monoclonal
5 μL/Test
PBS with 0.1% gelatin, 0.2% BSA and 0.09% sodium azide; pH 7.2
O60880
DSHP, EBVS, IMD5, LYP, MTCP1, SH2D1A, XLP, XLPD
Rat
Affinity chromatography
RUO
Antibody
Monoclonal
Human
Flow Cytometry
XLP-1D12
PE
SH2D1A
Liquid
SH2D1A
IgG2a, kappa
100 Tests
4° C, store in dark, DO NOT FREEZE!
Primary
4068
Videos
Documents

For Research Use Only.