SLAM Associated Protein (SAP) Rat anti-Human, PE, Clone: XLP-1D12, eBioscience™

Rat Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 12-9787-41

Code: NEW

Additional Details:
Additional Details: Weight: 0.23750kg



Disclaimers: For Research Use Only.

Product Code. 15587226

Quantity Price
1 £ 84.99 / 25 tests
Estimated Shipment date
from Supplier 03-04-2017
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Description and Specification

Specification

Species Reactivity Human
Format Conjugated
Isotype IgG2a
Applications Flow Cytometry (Intracellular Staining)
Gene Alias SH2D1A
Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material.
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Monoclonal or Polyclonal Monoclonal
Concentration 5μL (0.5μg)/test
Primary or Secondary Primary
Quantity 25 tests
Clone XLP-1D12
Antigen SLAM Associated Protein (SAP)
Host Species Rat
Regulatory Status RUO
Conjugate PE

The monoclonal antibody XLP-1D12 reacts with human SLAM-associated protein (SAP), which is also known as SH2D1A. SAP is a 15kDa SH2 domain-containing adaptor protein. Upon CD150/SLAM family receptor ligation, SAP recruits Fyn tyrosine kinase, which phosphorylates the receptor to activate downstream signaling events. SAP is expressed in thymocytes, T cells, NK cells, and NKT cells. Studies have demonstrated a role for SAP in promoting follicular T helper cell differentiation during germinal center formation. In addition, this protein is involved in NKT cell development, Th1/Th2 differentiation, development of innate T cells, and regulation of NK cell and CD8+ T cell cytotoxicity. Mutations of the gene encoding SAP results in X-linked lymphoproliferative (XLP) syndrome, which is characterized by impaired humoral immunity leading to increased susceptibility to Epstein-Barr virus infection and/or lymphoma. SAP has also been linked to automimmune diseases such as systemic lupus erythematosus.