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SLAM Associated Protein (SAP) Rat anti-Human, eFluor 660, Clone: XLP-1D12, eBioscience™

Rat Monoclonal Antibody

Brand:  Affymetrix eBioscience 50-9787-41

Code : NEW

Additional Details : Weight : 0.23750kg

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Product Code. 15560137

  • £84.99 / 25 tests


Estimated Shipment date
from Supplier 25-10-2017
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Disclaimers:

For Research Use Only.


Description

Description

The monoclonal antibody XLP-1D12 reacts with human SLAM-associated protein (SAP), which is also known as SH2D1A. SAP is a 15kDa SH2 domain-containing adaptor protein. Upon CD150/SLAM family receptor ligation, SAP recruits Fyn tyrosine kinase, which phosphorylates the receptor to activate downstream signaling events. SAP is expressed in thymocytes, T cells, NK cells, and NKT cells. Studies have demonstrated a role for SAP in promoting follicular T helper cell differentiation during germinal center formation. In addition, this protein is involved in NKT cell development, Th1/Th2 differentiation, development of innate T cells, and regulation of NK cell and CD8+ T cell cytotoxicity. Mutations of the gene encoding SAP results in X-linked lymphoproliferative (XLP) syndrome, which is characterized by impaired humoral immunity leading to increased susceptibility to Epstein-Barr virus infection and/or lymphoma. SAP has also been linked to automimmune diseases such as systemic lupus erythematosus.
Specifications

Specifications

SLAM Associated Protein (SAP)
XLP-1D12
eFluor 660
Conjugated
Rat
25 Tests
Store at 2-8°C. Do not freeze. Light-sensitive material.
Monoclonal
Flow Cytometry (Intracellular Staining)
5μL (0.03μg)/test
aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
SH2D1A
IgG2a
RUO
Primary
Human