Sino Biological™ SPP1 Recombinant Human Protein, His Tag

This recombinant protein is expressed from a DNA sequence encoding the pro form of human SPP1 (NP_001035147.1) (Met 1-Asn 314)fused to a polyhistidine tag at the C-terminus

Overview
Brand: Invitrogen

Manufacturer Part Number: 10352H08H25

UNSPSC: 12352202

Code: NEW

Additional Details:
Additional Details: Weight: 0.01000kg



Disclaimers: For Research Use Only. Not for use in diagnostic procedures.

Product Code. 15265255

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Description and Specification

Specification

Common Name Secreted phosphoprotein 1
Purity >80% by SDS-PAGE
Purification Method PAGE
Quantity 5 x 5μg
Gene Symbol SPP1
Protein Subtype Other Proteins
Endotoxin Concentration <1 EU/μg
Validated Application Assay Standard
Storage Requirements Store at -20°C. Store aliquots under sterile conditions at -20°C. Avoid repeated freeze-thaw cycles. Expires one year from date of receipt when stored as instructed.
Gene Alias BNSP, BSPI, ETA-1, mgC110940, OPN
Structural Form Full Length/Recombinant
Molecular Weight 35kDa
For Use With (Application) Proteins, Expression, Isolation & Analysis; Enzyme & Protein Activity Assays; Protein Assay Controls, Reference Standards & Accessories
Gene ID (Entrez) 6696
Termination C-Terminal
Expression System Mammalian
Protein Family Cell Structure/Organelle Proteins
Protein Tag His Tag
Format Lyophilized

Secreted Phosphoprotein 1 (SPP1) recombinant human protein is supplied as a lyophilized powder. This protein is suitable for use in analysis of protein structure. In general, recombinant proteins can also be used as an immunogen, as a protein standard, or in cell biology research applications.&line-break;Background: Secreted phosphoprotein 1, is a member of the osteopontin family. It is an extracellular structural protein and therefore an organic component of bone. Secreted phosphoprotein 1 is expressed in bone, although it is also expressed in other tissues. Secreted phosphoprotein 1 acts as a cytokine which is involved in enhancing production of interferon-gamma and interleukin-12 and reducing production of interleukin-10. It is essential in the pathway that leads to type I immunity. Secreted phosphoprotein 1 has been implicated as an important factor in bone remodeling. Specifically, research suggests it plays a role in anchoring osteoclasts to the mineral matrix of bones. The fact that Secreted phosphoprotein 1 interacts with multiple cell surface receptors which are ubiquitously expressed makes it an active player in many physiological and pathological processes including wound healing, bone turnover, tumorigenesis, inflammation and ischemia. Therefore, manipulation of plasma Secreted phosphoprotein 1 levels may be useful in the treatment of autoimmune diseases, cancer metastasis, osteoporosis and some forms of stress.
  • N-terminal Sequence Analysis: IIe 17
  • Activity: The activity of this protein has not been tested
  • Formulation: lyophilized in PBS, pH 7.4, 5% mannitol, 5% trehalose, 0.02% Tween®-80
  • Reconstitution: Dissolve the protein in sterile double-distilled water to a concentration of 0.2mg/mL or lower; aliquot and use as soon as possible

Manufactured by Sino Biological (China).