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IL6 Recombinant Human Protein, Invitrogen™ Sino Biological™

This recombinant protein is expressed from a DNA sequence encoding the mature form of human IL6 (NP_000591.1) (Val 30-Met 212) retaining the initial Met at the N-terminus

£66.75 - £324.00

Specifications

For Use With (Application) Protein Expression and Isolation, Enzyme and Protein Activity Assay, Protein Assay Control, Reference Standards and Accessories
Molecular Weight (g/mol) 20.3kDa
Storage Requirements Store at -20°C. Store aliquots under sterile conditions at -20°C. Avoid repeated freeze-thaw cycles. Expires one year from date of receipt when stored as instructed.
Structural Form Full Length/Recombinant
Gene Alias BSF2, HGF, HSF, IFNB2, IL-6
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Description

Description

Interleukin 6 (IL-6) recombinant human protein is supplied as a lyophilized powder. This protein is suitable for use in analysis of protein structure and performing cell based assays. It can also be used as an immunogen, as a protein standard, or in other research applications.
Background: Interleukin-6 (IL-6) is a multifunctional α-helical cytokine that regulates cell growth and differentiation of various tissues, and is known particularly for its role in the immune response and acute phase reactions. IL-6 is also involved in hematopoiesis, bone metabolism, and cancer progression, and has been defined an essential role in directing transition from innate to acquired immunity. IL-6 is secreted by a variety of cell types including T cells and macrophages as phosphorylated and variably glycosylated molecule with the molecular mass of 22-28kDa. Three IL-6 signaling pathways (STAT1, STAT3, and Ras-dependent MAPK cascade) have been reported. Dysregulated production of IL-6 and IL6R are implicated in the pathogenesis of several inflammatory diseases and malignancies such as multiple myeloma, rheumatoid arthritis, or osteoporosis.
  • N-terminal Sequence Analysis: Met
  • Activity: 1. Measured by its binding ability in a functional ELISA; immobilized recombinant human IL6 (100μL/well of a 8μg/mL solution) has been shown to bind recombinant human IL6R with a linear range of 1.25-20.0ng/mL; 2. Measured in a cell proliferation assay using TF1 human erythroleukemic cells, the EC50 for this effect is typically 0.2-0.8ng/mL
  • Formulation: lyophilized in 140mM NaCl, 2.7mM KCl, 10mM Na2HPO4, 1.8mM KH2PO4, pH 7.4, 5% mannitol, 5% trehalose, 0.02% Tween™-80
  • Reconstitution: Dissolve the protein in sterile double-distilled water to a concentration of 0.2mg/mL or lower; aliquot and use as soon as possible

Manufactured by Sino Biological (China).

Specifications

Specifications

Protein Expression and Isolation, Enzyme and Protein Activity Assay, Protein Assay Control, Reference Standards and Accessories
Store at -20°C. Store aliquots under sterile conditions at -20°C. Avoid repeated freeze-thaw cycles. Expires one year from date of receipt when stored as instructed.
BSF2, HGF, HSF, IFNB2, IL-6
IL6
E. coli
Lyophilized
≥95% by SDS-PAGE
20.3kDa
Full Length/Recombinant
Interleukin 6 (interferon, beta 2)
Untagged
Cytokines & Receptors
Interleukins
Videos
SDS
Documents

Documents

Product Certifications

For Research Use Only. Not for use in diagnostic procedures.