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IL6 Recombinant Human Protein, Invitrogen™ Sino Biological™
This recombinant protein is expressed from a DNA sequence encoding the mature form of human IL6 (NP_000591.1) (Val 30-Met 212) retaining the initial Met at the N-terminus
£66.75 - £324.00
Specifications
For Use With (Application) | Protein Expression and Isolation, Enzyme and Protein Activity Assay, Protein Assay Control, Reference Standards and Accessories |
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Molecular Weight (g/mol) | 20.3kDa |
Storage Requirements | Store at -20°C. Store aliquots under sterile conditions at -20°C. Avoid repeated freeze-thaw cycles. Expires one year from date of receipt when stored as instructed. |
Structural Form | Full Length/Recombinant |
Gene Alias | BSF2, HGF, HSF, IFNB2, IL-6 |
Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
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Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
13453009
|
Invitrogen
10395HNAE5 |
5μg |
This item is currently unavailable or has been discontinued. View the product page for possible alternatives. |
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13433009
|
Invitrogen
10395HNAE25 |
5 x 5μg |
This item is currently unavailable or has been discontinued. View the product page for possible alternatives. |
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13463009
|
Invitrogen
10395HNAE50 |
50μg |
This item is currently unavailable or has been discontinued. View the product page for possible alternatives. |
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Description
Interleukin 6 (IL-6) recombinant human protein is supplied as a lyophilized powder. This protein is suitable for use in analysis of protein structure and performing cell based assays. It can also be used as an immunogen, as a protein standard, or in other research applications.Background: Interleukin-6 (IL-6) is a multifunctional α-helical cytokine that regulates cell growth and differentiation of various tissues, and is known particularly for its role in the immune response and acute phase reactions. IL-6 is also involved in hematopoiesis, bone metabolism, and cancer progression, and has been defined an essential role in directing transition from innate to acquired immunity. IL-6 is secreted by a variety of cell types including T cells and macrophages as phosphorylated and variably glycosylated molecule with the molecular mass of 22-28kDa. Three IL-6 signaling pathways (STAT1, STAT3, and Ras-dependent MAPK cascade) have been reported. Dysregulated production of IL-6 and IL6R are implicated in the pathogenesis of several inflammatory diseases and malignancies such as multiple myeloma, rheumatoid arthritis, or osteoporosis.
- N-terminal Sequence Analysis: Met
- Activity: 1. Measured by its binding ability in a functional ELISA; immobilized recombinant human IL6 (100μL/well of a 8μg/mL solution) has been shown to bind recombinant human IL6R with a linear range of 1.25-20.0ng/mL; 2. Measured in a cell proliferation assay using TF1 human erythroleukemic cells, the EC50 for this effect is typically 0.2-0.8ng/mL
- Formulation: lyophilized in 140mM NaCl, 2.7mM KCl, 10mM Na2HPO4, 1.8mM KH2PO4, pH 7.4, 5% mannitol, 5% trehalose, 0.02% Tween™-80
- Reconstitution: Dissolve the protein in sterile double-distilled water to a concentration of 0.2mg/mL or lower; aliquot and use as soon as possible
Manufactured by Sino Biological (China).
Specifications
Protein Expression and Isolation, Enzyme and Protein Activity Assay, Protein Assay Control, Reference Standards and Accessories | |
Store at -20°C. Store aliquots under sterile conditions at -20°C. Avoid repeated freeze-thaw cycles. Expires one year from date of receipt when stored as instructed. | |
BSF2, HGF, HSF, IFNB2, IL-6 | |
IL6 | |
E. coli | |
Lyophilized | |
≥95% by SDS-PAGE |
20.3kDa | |
Full Length/Recombinant | |
Interleukin 6 (interferon, beta 2) | |
Untagged | |
Cytokines & Receptors | |
Interleukins |
For Research Use Only. Not for use in diagnostic procedures.