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CD4 Recombinant Human Protein, hIgG1-Fc.His Tag, Invitrogen™ Sino Biological™

This recombinant human protein is expressed from a DNA sequence encoding the extracellular domain (Met 1-Trp 390) of human CD4 (NP_000607.1) fused to the polyhistidine-tagged Fc region of human IgG1 at the C-terminus

£58.15 - £920.00

Specifications

Purity ≥90% by SDS-PAGE
Endotoxin Concentration <1 EU/μg
Format Lyophilized
Gene Alias CD4mut
Gene ID (Entrez) 920
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Products 4
Product Code Brand Quantity Price Quantity & Availability  
Product Code Brand Quantity Price Quantity & Availability  
13415876 View Documents Invitrogen
10400H03H5
5μg £58.15
5µg View alternative products
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Estimated Shipment date
from Supplier 18-06-2020
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13405876 View Documents Invitrogen
10400H03H25
5 x 5μg £143.00
25µg View alternative products
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Estimated Shipment date
from Supplier 18-06-2020
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13435876 View Documents Invitrogen
10400H03H50
50μg £255.00
50µg View alternative products
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Estimated Shipment date
from Supplier 18-06-2020
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13425876 View Documents Invitrogen
10400H03H250
5 x 50μg £920.00
250µg View alternative products
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Estimated Shipment date
from Supplier 18-06-2020
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Description

Description

Cluster of Differentiation 4 (CD4) recombinant human protein is supplied as a lyophilized powder. This protein is suitable for use in the study of protein-protein interactions, and cell biology research applications. It can also be used as a protein standard.
Background: Human T-cell surface glycoprotein CD4, also known as T-cell surface antigen T4/Leu-3, is a single-pass type I membrane protein. CD4 contains three Ig-like C2-type (immunoglobulin-like) domains and one Ig-like V-type (immunoglobulin-like) domain. CD4 is a glycoprotein expressed on the surface of T helper cells, regulatory T cells, monocytes, macrophages, and dendritic cells. CD4 amplifies the signal generated by the TCR. CD4 interacts directly with MHC class II molecules on the surface of the antigen presenting cell via its extracellular domain. CD4 is a primary receptor used by HIV-1 to gain entry into host T cells. HIV infection leads to a progressive reduction of the number of T cells possessing CD4 receptors. Therefore, medical professionals refer to the CD4 count to decide when to begin treatment for HIV-infected patients.
  • N-terminal Sequence Analysis: Lys26
  • Activity: measured by its binding ability in a functional ELISA; immobilized human CD4-His at 2μg/well has been shown to bind biotinylated HIV-1 GP120 with a linear range of 0.078-1.25μg/mL
  • Formulation: lyophilized in PBS, pH 7.4, 5% mannitol, 5% trehalose, and 0.02% Tween™-80
  • Reconstitution: Dissolve the protein in sterile double-distilled water to a concentration of 0.2mg/mL or lower; aliquot and use as soon as possible

Shipping Condition: Room Temperature. Manufactured by Sino Biological (China).

Specifications

Specifications

≥90% by SDS-PAGE
Lyophilized
920
<1 EU/μg
CD4mut

For Research Use Only. Not for use in diagnostic procedures.