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CD19 Recombinant Human Protein, His Tag, Invitrogen™ Sino Biological™
This recombinant protein is expressed from a DNA sequence encoding the extracellular domain (Met 1-Lys 291) of human CD19 (AAB60697) fused to a polyhistidine tag at the C-terminus
Brand: Invitrogen 11880H08H50
Code : NEW
Additional Details : Weight : 0.01000kg
Description
Cluster of Differentiation 19 (CD19) recombinant human protein is supplied as a lyophilized powder. This protein is suitable for use in analysis of protein structure the study of protein-protein interactions, and cell biology research applications. It can also be used as an immunogen, or as a protein standard.&line-break;Background: Cluster of Differentiation 19 (CD19), is a single-pass type I membrane protein which contains two Ig-like C2-type (immunoglobulinlike) domains. CD19 forms a complex with CD21, CD81 and CD225 in the membrane of mature B cells. It interacts with VAV. It interacts with GRB2 and SOS when phosphorylated on Tyr-348 and/or Tyr-378. CD19 also interacts with PLCG2 when phosphorylated on Tyr-409. CD19 is an important pan B cell marker and co-stimulatory protein in humans and mice. CD19 is a hallmark differentiation antigen of the B cell lineage and positively regulates antigen receptor signal transduction in mature B cells. CD19 defines signaling thresholds for the Ag receptor as well as other cell surface receptors that regulate B lymphocyte selection, activation, and differentiation. Defects in CD19 are a cause of hypogammaglobulinemia.- N-terminal Sequence Analysis: Pro 20
- Activity: Measured by its binding ability in a functional ELISA; immobilized human CD19 at 2μg/mL (100μL/well) has been shown to bind biotinylated human CD9 with a linear range of 0.032-0.8μg/mL
- Formulation: lyophilized in PBS, pH 7.4, 5% mannitol, 5% trehalose, and 0.02% Tween™-80
- Reconstitution: Dissolve the protein in sterile double-distilled water to a concentration of 0.2mg/mL or lower; aliquot and use as soon as possible
Shipping Condition: Room Temperature. Manufactured by Sino Biological (China).
Specifications
Protein Expression and Isolation, Enzyme and Protein Activity Assay, Protein Assay Control, Reference Standards and Accessories | |
31.6kDa | |
Store at -20° to -70°C. Store aliquots under sterile conditions at -20°C. Avoid repeated freeze-thaw cycles. Expires one year from date of receipt when stored as instructed. | |
<1 EU/μg | |
CD19 molecule | |
His Tag | |
CD Proteins | |
Other Proteins |
930 | |
50μg | |
Truncated/Recombinant/Cell Surface Protein | |
B4, mgC12802 | |
CD19 | |
Mammalian | |
Lyophilized | |
≥90% by SDS-PAGE |
For Research Use Only. Not for use in diagnostic procedures.