Sino Biological™ ACVR2B Recombinant Human Protein (without Catalytic Activity Domain), hIgG1-Fc Tag

This recombinant protein was expressed from a DNA sequence encoding the N-terminal segment (Met 1-Thr 134) from the extracellular domain of human ACVR2B (NP_001097.2) was expressed with the fused human IgG1 Fc region at the C-terminus

Overview
Brand: Invitrogen

Manufacturer Part Number: 10229H02H50

RECOM HU ACVR2B (HIGG1-FC)

UNSPSC: 12352202

Code: NEW

Additional Details:
Additional Details: Weight: 0.10000kg



Disclaimers: For Research Use Only. Not for use in diagnostic procedures.

Product Code. 15224955

Quantity Price
1 £ 158.0 / 50µg
Estimated Shipment date
from Supplier 07-12-2016
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Description and Specification

Specification

For Use With (Application) Proteins, Expression, Isolation & Analysis; Enzyme & Protein Activity Assays; Protein Assay Controls, Reference Standards & Accessories
Quantity 50μg
Storage Requirements Store at -20°C. Store aliquots under sterile conditions at -20°C. Avoid repeated freeze-thaw cycles. Expires one year from date of receipt when stored as instructed.
Protein Family Growth Factors & Receptors

Activin Receptor IIB (ACVR2B), recombinant human protein is supplied as a lyophilized powder. In general, recombinant proteins are suitable for use in studying protein-protein interactions, analysis of protein structure, and performing cell based assays. It can also be used as an immunogen, as a protein standard, or in other research applications.
  • Activity: 1. Measured by its dose-dependent blocking of myostatin inhibition on murine MPC-11 cell proliferation, approximately 11ng/mL of recombinant human ActivinR-IIB/Fc Chimera will inhibit 50% of the biological response due to 4ng/mL of myostatin; 2. Measured by its binding ability in a functional ELISA; 3. Immobilized human ACVR2B (Mfr. No. 10229-H02H) at 10μg/mL (100μL/well) can bind biotinylated human INHBA-His (Mfr. No. 10429-H08H), the EC50 of biotinylated human INHBA-His (Mfr. No. 10429-H08H) is 0.112μg/mL; 4. Immobilized human ACVR2B (Mfr. No. 10229-H02H) at 10μg/mL (100μL/well) can bind biotinylated mouse INHBA-His (Mfr. No. 50659-M08H), the EC50 of biotinylated mouse INHBA-His (Mfr. No. 50659-M08H) is 0.161μg/mL
  • Formulation: 140mM NaCl, 2.7mM KCl, 10mM Na2HPO4, 1.8mM KH2PO4, pH 7.4, 5% Mannitol, 5% Trehalose, 0.02% Tween 80
  • Reconstitution: Dissolve the protein in sterile double distilled water to a concentration of 0.2mg/mL or lower; aliquot and use as soon as possible

This protein is manufactured by Sino Biological Inc.