Siglec G Mouse anti-Mouse, APC, Clone: SH2.1, eBioscience™

Mouse Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 17-5833-82

Code: NEW

Additional Details:
Additional Details: Weight: 0.09500kg



Disclaimers: For Research Use Only.

Product Code. 15518146

Quantity Price
1 £ 219.5 / 100µg
EU Stock 3
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Description and Specification

Specification

Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material.
Clone SH2.1
Conjugate APC
Isotype IgG1
Applications Flow Cytometry
Concentration 0.2mg/mL
Monoclonal or Polyclonal Monoclonal
Gene Alias sialic acid-binding immunoglobulin-like lectin-G
Species Reactivity Mouse
Format Conjugated
Quantity 100μg
Primary or Secondary Primary
Host Species Mouse
Antigen Siglec G
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Regulatory Status RUO

The SH2.1 monoclonal antibody reacts with mouse siglec-G, which is also known as sialic acid-binding immunoglobulin-like lectin-G. Siglec-G is an inhibitory receptor that is expressed in a B cell-specific manner with B1 B cells expressing the highest levels of siglec-G. When overexpressed, siglec-G inhibits B cell receptor-mediated calcium signaling. Siglec-G-deficient mice show a massive expansion of the B1a cell population as well as higher titers of natural IgM antibodies. Siglec-G-deficient B1a cells show a lower level of spontaneous apoptosis and a prolonged life span, which may result from higher expression levels of the transcription factor NFATc1. Siglec-G-dependent negative regulation exists in B1 cells, which may explain the naturally muted signaling response of B1 cells.