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Siglec-G Monoclonal Antibody (SH2.1), APC, eBioscience™, Invitrogen™
Mouse Monoclonal Antibody
Brand: Affymetrix eBioscience 17-5833-82
195.34 GBP valid until 2024-03-29
Use promo code "21615" to get your promotional price.
Code : NEW
Additional Details : Weight : 0.09500kg
Description
Description: The SH2.1 monoclonal antibody reacts with mouse siglec-G, which is also known as sialic acid-binding immunoglobulin-like lectin-G. Siglec-G is an inhibitory receptor that is expressed in a B cell-specific manner with B1 B cells expressing the highest levels of siglec-G. When overexpressed, siglec-G inhibits B cell receptor-mediated calcium signaling. Siglec-G-deficient mice show a massive expansion of the B1a cell population as well as higher titers of natural IgM antibodies. Siglec-G-deficient B1a cells show a lower level of spontaneous apoptosis and a prolonged life span, which may result from higher expression levels of the transcription factor NFATc1. Siglec-G-dependent negative regulation exists in B1 cells, which may explain the naturally muted signaling response of B1 cells. Applications Reported: This SH2.1 antibody has been reported for use in flow cytometric analysis. Applications Tested: This SH2.1 antibody has been tested by flow cytometric analysis of mouse splenocytes. This can be used at less than or equal to 0.125 μg per test. A test is defined as the amount (μg) of antibody that will stain a cell sample in a final volume of 100 μL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest. Excitation: 633-647 nm; Emission: 660 nm; Laser: Red Laser. Filtration: 0.
Siglec-G Monoclonal antibody specifically detects Siglec-G in Mouse samples. It is validated for Flow Cytometry.Specifications
Siglec-G | |
Monoclonal | |
0.2 mg/mL | |
PBS with 0.09% sodium azide; pH 7.2 | |
Q80ZE3 | |
Siglecg | |
Affinity chromatography | |
RUO | |
243958 | |
4° C, store in dark, DO NOT FREEZE! | |
Liquid |
Flow Cytometry | |
SH2.1 | |
APC | |
Siglecg | |
9830164H23; A630096C01Rik; mSiglec-G; sialic acid binding Ig-like lectin 10; sialic acid binding Ig-like lectin G; sialic acid-binding Ig-like lectin 10; Sialic acid-binding Ig-like lectin G; Siglec; Siglec 10; Siglec10; Siglec-10; Siglecg; Siglec-G | |
Mouse | |
100 μg | |
Primary | |
Mouse | |
Antibody | |
IgG1 κ |
For Research Use Only.