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Siglec G Mouse anti-Mouse, APC, Clone: SH2.1, eBioscience™

Mouse Monoclonal Antibody

Brand:  Affymetrix eBioscience 17-5833-80

Code : NEW

Additional Details : Weight : 0.09500kg

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Product Code. 15508146

  • £88.66 / 25µg


EU Stock 2
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Disclaimers:

For Research Use Only.


Specifications

Description

The SH2.1 monoclonal antibody reacts with mouse siglec-G, which is also known as sialic acid-binding immunoglobulin-like lectin-G. Siglec-G is an inhibitory receptor that is expressed in a B cell-specific manner with B1 B cells expressing the highest levels of siglec-G. When overexpressed, siglec-G inhibits B cell receptor-mediated calcium signaling. Siglec-G-deficient mice show a massive expansion of the B1a cell population as well as higher titers of natural IgM antibodies. Siglec-G-deficient B1a cells show a lower level of spontaneous apoptosis and a prolonged life span, which may result from higher expression levels of the transcription factor NFATc1. Siglec-G-dependent negative regulation exists in B1 cells, which may explain the naturally muted signaling response of B1 cells.
Description & Specifications

Specifications

Siglec G
SH2.1
Allophycocyanin
Conjugated
Murine
25μg
Store at 2-8°C. Do not freeze. Light-sensitive material.
Monoclonal
Flow Cytometry
0.2mg/mL
aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
sialic acid-binding immunoglobulin-like lectin-G
IgG1
RUO
Primary
Murine