missing translation for 'onlineSavingsMsg'
Learn More

SD 208, Tocris Bioscience™

Potent ATP-competitive TGF-βRI inhibitor

Brand:  Tocris (Bio-Techne) 326950

Code : Z1

Additional Details : Weight : 0.01000kg

Quantity 50mg

 View more versions of this product

Product Code. 13442694

  • £689.43 / 50mg

Estimated Shipment date
from Supplier 19-12-2019

Please to purchase this item. Need a web account? Register with us today!


Description

Description

Potent, orally active ATP-competitive transforming growth factor-β receptor 1 (TGF-βRI) inhibitor (IC50 = 49 nM). Displays > 100-fold and > 17-fold selectivity over TGF-βRII and other common kinases respectively. Exhibits anti-inflammatory and antitumor activity. Also promotes an antiglioma immune response. Ameliorates germinal matrix hemorrhage-induced neurological deficits in neonatal rats.
Specifications

Chemical Identifiers

627536-09-8
352.757
alk5 inhibitor v, 2-5-chloro-2-fluorophenyl-4-4-pyridyl amino pteridine, 2-5-chloro-2-fluorophenyl-n-pyridin-4-yl pteridin-4-amine, 2-5-chloro-2-fluorophenyl pteridin-4-yl pyridin-4-yl-amine, 2-5-chloro-2-fluorophenyl-n-pyridin-4-ylpteridin-4-amine, 2-5-chloro-2-fluorophenyl pteridin-4-yl pyridin-4-yl amine, transforming growth factor-beta type i receptor kinase inhibitor v, d0v8ac, tgf-, a ri kinase inhibitor v, tgf-ri kinase inhibitor v
2-(5-chloro-2-fluorophenyl)-N-pyridin-4-ylpteridin-4-amine
C17H10ClFN6
BERLXWPRSBJFHO-UHFFFAOYSA-N
10316032
C1=CC(=C(C=C1Cl)C2=NC3=NC=CN=C3C(=N2)NC4=CC=NC=C4)F

Specifications

50mg
627536-09-8
alk5 inhibitor v, 2-5-chloro-2-fluorophenyl-4-4-pyridyl amino pteridine, 2-5-chloro-2-fluorophenyl-n-pyridin-4-yl pteridin-4-amine, 2-5-chloro-2-fluorophenyl pteridin-4-yl pyridin-4-yl-amine, 2-5-chloro-2-fluorophenyl-n-pyridin-4-ylpteridin-4-amine, 2-5-chloro-2-fluorophenyl pteridin-4-yl pyridin-4-yl amine, transforming growth factor-beta type i receptor kinase inhibitor v, d0v8ac, tgf-, a ri kinase inhibitor v, tgf-ri kinase inhibitor v
C1=CC(=C(C=C1Cl)C2=NC3=NC=CN=C3C(=N2)NC4=CC=NC=C4)F
352.757
352.75
SD 208
C17H10ClFN6
BERLXWPRSBJFHO-UHFFFAOYSA-N
2-(5-chloro-2-fluorophenyl)-N-pyridin-4-ylpteridin-4-amine
10316032
>98%
Videos
Documents