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SC 514, Tocris Bioscience™

IKKβ inhibitor; attenuates NF-κB-induced gene expression

Brand:  Tocris (Bio-Techne) 331850

Code : Z1

Additional Details : Weight : 0.01000kg

Quantity 50mg

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Product Code. 13462774

  • £427.72 / 50mg


Estimated Shipment
31-10-2018
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Description

Description

Orally active, ATP-competitive IKKβ inhibitor (IC50 = 3 - 12μM) that displays > 10-fold selectivity over 28 other kinases including JNK, p38, MK2 and ERK. Attenuates NF-κB-induced gene expression of IL-6, IL-8 and COX-2 in synovial fibroblasts (IC50 values are 20, 20 and 8μM respectively). Reduces iNOS induction and exhibits anti-inflammatory activity in vivo.
Specifications

Chemical Identifiers

354812-17-2
224.296
3-amino-5-thiophen-3-yl thiophene-2-carboxamide, 4-amino-2,3'-bithiophene-5-carboxamide, ikk-2 inhibitor, sc-514, insolution ikk-2 inhibitor, sc-514, 5-thien-3-yl-3-aminothiophene-2-carboxamide, curator_000007, 4-amino-2,3-bithiophene-5-carboxamide, biomolki_000076, biomolki2_000080, d0t6va
3-amino-5-thiophen-3-ylthiophene-2-carboxamide
C9H8N2OS2
BMUACLADCKCNKZ-UHFFFAOYSA-N
2807869
C1=CSC=C1C2=CC(=C(S2)C(=O)N)N

Specifications

SC 514
354812-17-2
3-amino-5-thiophen-3-yl thiophene-2-carboxamide, 4-amino-2,3'-bithiophene-5-carboxamide, ikk-2 inhibitor, sc-514, insolution ikk-2 inhibitor, sc-514, 5-thien-3-yl-3-aminothiophene-2-carboxamide, curator_000007, 4-amino-2,3-bithiophene-5-carboxamide, biomolki_000076, biomolki2_000080, d0t6va
C1=CSC=C1C2=CC(=C(S2)C(=O)N)N
224.296
224.3
50mg
C9H8N2OS2
BMUACLADCKCNKZ-UHFFFAOYSA-N
3-amino-5-thiophen-3-ylthiophene-2-carboxamide
2807869
>98%
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