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SC 514, Tocris Bioscience™

IKKβ inhibitor; attenuates NF-κB-induced gene expression

Brand:  Tocris (Bio-Techne) 331850

Code : Z1

Additional Details : Weight : 0.01000kg

Quantity 50mg

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Product Code. 13462774

  • £440.00 / 50mg


Estimated Shipment
02-07-2018
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Description

Description

Orally active, ATP-competitive IKKβ inhibitor (IC50 = 3 - 12μM) that displays > 10-fold selectivity over 28 other kinases including JNK, p38, MK2 and ERK. Attenuates NF-κB-induced gene expression of IL-6, IL-8 and COX-2 in synovial fibroblasts (IC50 values are 20, 20 and 8μM respectively). Reduces iNOS induction and exhibits anti-inflammatory activity in vivo.
Specifications

Chemical Identifiers

SC 514
C9H8N2OS2
224.3
4-Amino-[2', 3'-bithiophene]-5-carboxamide

Specifications

SC 514
>98%
224.3
4-Amino-[2', 3'-bithiophene]-5-carboxamide
354812-17-2
C9H8N2OS2
50mg
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