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SBE 13 hydrochloride, Tocris Bioscience™

Potent and selective PLK1 inhibitor

£92.61 - £327.81

Chemical Identifiers

CAS 1052532-15-6
Molecular Formula C24H28Cl2N2O4
Molecular Weight (g/mol) 479.398
InChI Key QBGSVDJLQQXEGG-UHFFFAOYSA-N
Synonym sbe13 hydrochloride, sbe 13 hydrochloride, sbe 13 hcl, n-4-6-chloro-3-pyridinyl methoxy-3-methoxyphenyl methyl-3,4-dimethoxybenzeneethanamine hydrochloride, n-4-6-chloropyridin-3-yl methoxy-3-methoxybenzyl-2-3,4-dimethoxyphenyl ethanamine, c24h27cln2o4.clh, sbe-13 hcl;sbe13 hcl, sbe 13 hydrochloride hplc, n-4-6-chloropyridin-3-yl methoxy-3-methoxyphenyl methyl-2-3,4-dimethoxyphenyl ethan-1-amine-hydrogen chloride 1/1
PubChem CID 11948807
IUPAC Name N-[[4-[(6-chloropyridin-3-yl)methoxy]-3-methoxyphenyl]methyl]-2-(3,4-dimethoxyphenyl)ethanamine;hydrochloride
SMILES COC1=C(C=C(C=C1)CCNCC2=CC(=C(C=C2)OCC3=CN=C(C=C3)Cl)OC)OC.Cl
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Products 2
Product Code Brand Quantity Price Quantity & Availability  
Product Code Brand Quantity Price Quantity & Availability  
13434504 View Documents RD Systems (Bio-Techne)
4292/10
10mg £92.61
10mg View alternative products
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Estimated Shipment date
from Supplier 17-12-2019
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13444504 View Documents RD Systems (Bio-Techne)
4292/50
50mg £327.81
50mg View alternative products
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»
Estimated Shipment date
from Supplier 17-12-2019
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Description

Description

Selective inhibitor of PLK1 (IC50 values are 200 pM, 875 nM and 66 μM for PLK1, PLK3 and PLK2 respectively). Exhibits no effect on Aurora kinase A activity. Binds and stabilizes the inactive form of PLK1. Delays cell cycle progression, reduces cell proliferation and induces apoptosis in a range of human cancer cell lines. Transiently arrests cells cycle at G0/G1 in primary cells.
Specifications

Chemical Identifiers

1052532-15-6
479.398
sbe13 hydrochloride, sbe 13 hydrochloride, sbe 13 hcl, n-4-6-chloro-3-pyridinyl methoxy-3-methoxyphenyl methyl-3,4-dimethoxybenzeneethanamine hydrochloride, n-4-6-chloropyridin-3-yl methoxy-3-methoxybenzyl-2-3,4-dimethoxyphenyl ethanamine, c24h27cln2o4.clh, sbe-13 hcl;sbe13 hcl, sbe 13 hydrochloride hplc, n-4-6-chloropyridin-3-yl methoxy-3-methoxyphenyl methyl-2-3,4-dimethoxyphenyl ethan-1-amine-hydrogen chloride 1/1
N-[[4-[(6-chloropyridin-3-yl)methoxy]-3-methoxyphenyl]methyl]-2-(3,4-dimethoxyphenyl)ethanamine;hydrochloride
C24H28Cl2N2O4
QBGSVDJLQQXEGG-UHFFFAOYSA-N
11948807
COC1=C(C=C(C=C1)CCNCC2=CC(=C(C=C2)OCC3=CN=C(C=C3)Cl)OC)OC.Cl

Specifications

10mg
1052532-15-6
sbe13 hydrochloride, sbe 13 hydrochloride, sbe 13 hcl, n-4-6-chloro-3-pyridinyl methoxy-3-methoxyphenyl methyl-3,4-dimethoxybenzeneethanamine hydrochloride, n-4-6-chloropyridin-3-yl methoxy-3-methoxybenzyl-2-3,4-dimethoxyphenyl ethanamine, c24h27cln2o4.clh, sbe-13 hcl;sbe13 hcl, sbe 13 hydrochloride hplc, n-4-6-chloropyridin-3-yl methoxy-3-methoxyphenyl methyl-2-3,4-dimethoxyphenyl ethan-1-amine-hydrogen chloride 1/1
COC1=C(C=C(C=C1)CCNCC2=CC(=C(C=C2)OCC3=CN=C(C=C3)Cl)OC)OC.Cl
479.398
479.4
SBE 13 hydrochloride
C24H28Cl2N2O4
QBGSVDJLQQXEGG-UHFFFAOYSA-N
N-[[4-[(6-chloropyridin-3-yl)methoxy]-3-methoxyphenyl]methyl]-2-(3,4-dimethoxyphenyl)ethanamine;hydrochloride
11948807
>99%