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SB 590885, Tocris Bioscience™

Potent B-Raf inhibitor

Brand:  RD Systems (Bio-Techne) 2650/10

Code : Z1

Additional Details : Weight : 0.00010kg

Quantity 10mg

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Product Code. 13441654

  • £186.69 / 10mg

Estimated Shipment date
from Supplier 21-11-2019

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Description

Description

Potent B-Raf inhibitor (Kd = 0.3 nM). Selective for B-Raf against 46 other kinases (Ki app values are 0.16 and 1.72 nM for B-Raf and c-Raf respectively). Decreases anchorage-independent growth of melanoma cell lines. Inhibits ERK phosphorylation and proliferation in tumor cells expressing B-RafV600E.
Specifications

Chemical Identifiers

405554-55-4
453.546
5-2-4-2-dimethylamino ethoxy phenyl-5-4-pyridinyl-1h-imidazol-4-yl-2,3-dihydro-1h-inden-1-one oxime, 2-4-4-1e-1-hydroxyimino-2,3-dihydroinden-5-yl-5-pyridin-4-yl-1h-imidazol-2-yl phenoxy ethyl dimethylamine, 2-4-4-1z-1-hydroxyimino-2,3-dihydroinden-5-yl-5-pyridin-4-yl-1h-imidazol-2-yl phenoxy ethyl dimethylamine, 2-4-4-1-hydroxyimino-2,3-dihydroinden-5-yl-5-pyridin-4-yl-1h-imidazol-2-yl phenoxy ethyl dimethylamine
N,N-dimethyl-2-[4-[4-(1-nitroso-2,3-dihydroinden-5-ylidene)-5-(1H-pyridin-4-ylidene)-1H-imidazol-2-yl]phenoxy]ethanamine
C27H27N5O2
DPCXEUSDRQOOGZ-UHFFFAOYSA-N
53239990
CN(C)CCOC1=CC=C(C=C1)C2=NC(=C3C=CC4=C(CCC4=C3)N=O)C(=C5C=CNC=C5)N2

Specifications

10mg
405554-55-4
5-2-4-2-dimethylamino ethoxy phenyl-5-4-pyridinyl-1h-imidazol-4-yl-2,3-dihydro-1h-inden-1-one oxime, 2-4-4-1e-1-hydroxyimino-2,3-dihydroinden-5-yl-5-pyridin-4-yl-1h-imidazol-2-yl phenoxy ethyl dimethylamine, 2-4-4-1z-1-hydroxyimino-2,3-dihydroinden-5-yl-5-pyridin-4-yl-1h-imidazol-2-yl phenoxy ethyl dimethylamine, 2-4-4-1-hydroxyimino-2,3-dihydroinden-5-yl-5-pyridin-4-yl-1h-imidazol-2-yl phenoxy ethyl dimethylamine
CN(C)CCOC1=CC=C(C=C1)C2=NC(=C3C=CC4=C(CCC4=C3)N=O)C(=C5C=CNC=C5)N2
453.546
453.54
SB 590885
C27H27N5O2
DPCXEUSDRQOOGZ-UHFFFAOYSA-N
N,N-dimethyl-2-[4-[4-(1-nitroso-2,3-dihydroinden-5-ylidene)-5-(1H-pyridin-4-ylidene)-1H-imidazol-2-yl]phenoxy]ethanamine
53239990
>98%
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