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SB 431542, Tocris Bioscience™

Potent, selective inhibitor of TGF-βRI, ALK4 and ALK7

Brand:  Tocris (Bio-Techne) 1614/10

Code : Z1

Additional Details : Weight : 0.01100kg

Quantity 10mg

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Product Code. 13429803

  • £279.30 / 10mg

Estimated Shipment date
from Supplier 25-03-2020

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Description

Description

Potent and selective inhibitor of the transforming growth factor-β (TGF-β) type I receptor/ALK5 (IC50 = 94 nM), and its relatives ALK4 and ALK7. Suppresses TGF-β-induced proliferation of human osteosarcoma cells. Replaces SOX2 in reprogramming of fibroblasts into iPSCs. Stimulates proliferation, differentiation and sheet formation of ESC-derived endothelial cells. Inhibits TGF-β-induced EMT, migration, invasion and VEGF secretion in several human cancer cell lines.

SB 431542 synthesized to cGMP guidelines also available.

Specifications

Chemical Identifiers

301836-41-9
384.395
4-4-benzo d 1,3 dioxol-5-yl-5-pyridin-2-yl-1h-imidazol-2-yl benzamide, unii-e1557v1v0n, 4-4-1,3-benzodioxol-5-yl-5-2-pyridinyl-1h-imidazol-2-yl benzamide, 4-4-1,3-benzodioxole-5-yl-5-2-pyridyl-1h-imidazole-2-yl benzamide, 4-4-2h-1,3-benzodioxol-5-yl-5-pyridin-2-yl-1h-imidazol-2-yl benzamide, sb 431542 hydrate, 4-4-benzo 1,3 dioxol-5-yl-5-pyridin-2-yl-1h-imidazol-2-yl-benzamide, 4-5-benzo 1,3 dioxol-5-yl-4-pyridin-2-yl-1h-imidazol-2-yl-benzamide, 4-4-1,3-benzodioxol-5-yl-5-pyridin-2-yl-1h-imidazol-2-yl benzamide, benzamide, 4-4-1,3-benzodioxol-5-yl-5-2-pyridinyl-1h-imidazol-2-yl
4-[4-(1,3-benzodioxol-5-yl)-5-pyridin-2-yl-1H-imidazol-2-yl]benzamide
C22H16N4O3
FHYUGAJXYORMHI-UHFFFAOYSA-N
4521392
C1OC2=C(O1)C=C(C=C2)C3=C(NC(=N3)C4=CC=C(C=C4)C(=O)N)C5=CC=CC=N5

Specifications

10mg
301836-41-9
4-4-benzo d 1,3 dioxol-5-yl-5-pyridin-2-yl-1h-imidazol-2-yl benzamide, unii-e1557v1v0n, 4-4-1,3-benzodioxol-5-yl-5-2-pyridinyl-1h-imidazol-2-yl benzamide, 4-4-1,3-benzodioxole-5-yl-5-2-pyridyl-1h-imidazole-2-yl benzamide, 4-4-2h-1,3-benzodioxol-5-yl-5-pyridin-2-yl-1h-imidazol-2-yl benzamide, sb 431542 hydrate, 4-4-benzo 1,3 dioxol-5-yl-5-pyridin-2-yl-1h-imidazol-2-yl-benzamide, 4-5-benzo 1,3 dioxol-5-yl-4-pyridin-2-yl-1h-imidazol-2-yl-benzamide, 4-4-1,3-benzodioxol-5-yl-5-pyridin-2-yl-1h-imidazol-2-yl benzamide, benzamide, 4-4-1,3-benzodioxol-5-yl-5-2-pyridinyl-1h-imidazol-2-yl
C1OC2=C(O1)C=C(C=C2)C3=C(NC(=N3)C4=CC=C(C=C4)C(=O)N)C5=CC=CC=N5
384.395
384.39
SB 431542
C22H16N4O3
FHYUGAJXYORMHI-UHFFFAOYSA-N
4-[4-(1,3-benzodioxol-5-yl)-5-pyridin-2-yl-1H-imidazol-2-yl]benzamide
4521392
>99%
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