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SB 216763, Tocris Bioscience™

Potent, selective GSK-3 inhibitor

Brand:  RD Systems (Bio-Techne) 16161

Code : Z1

Additional Details : Weight : 0.01000kg

Quantity 1mg

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Product Code. 13469803

  • £92.61 / 1mg

Estimated Shipment date
from Supplier 25-03-2020

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Description

Description

Potent and selective, ATP-competitive glycogen synthase kinase-3 (GSK-3) inhibitor (IC50 = 34.3 nM for GSK-3α). Equally effective at inhibiting human GSK-3α and GSK-3β. Exhibits minimal activity against 24 other protein kinases (IC50 >10 μM). Stimulates glycogen synthesis in liver cells, and induces β-catenin-dependent gene transcription. Neuroprotective; also reduces pulmonary inflammation and fibrosis in a mouse model. Shown to maintain mouse embryonic stem cells in a pluripotent state.
Specifications

Chemical Identifiers

280744-09-4
371.217
3-2,4-dichlorophenyl-4-1-methyl-1h-indol-3-yl-1h-pyrrole-2,5-dione, 1h-pyrrole-2,5-dione, 3-2,4-dichlorophenyl-4-1-methyl-1h-indol-3-yl, 3-2,4-dichlorophenyl-4-1-methylindol-3-yl pyrrole-2,5-dione, 3-2,4-dichlorophenyl-4-1-methylindol-3-yl-1h-pyrrole-2,5-dione, 3-2,4-dichlorophenyl-4-1-methyl-1h-indol-3-yl-2,5-dihydro-1h-pyrrole-2,5-dione, tocris-1616, lopac-s-3442, d0a1yq, sb hplc, 3-2,4-dichlorophenyl-4-1-methyl-1h-indol-3-yl
3-(2,4-dichlorophenyl)-4-(1-methylindol-3-yl)pyrrole-2,5-dione
C19H12Cl2N2O2
JCSGFHVFHSKIJH-UHFFFAOYSA-N
176158
CN1C=C(C2=CC=CC=C21)C3=C(C(=O)NC3=O)C4=C(C=C(C=C4)Cl)Cl

Specifications

1mg
280744-09-4
3-2,4-dichlorophenyl-4-1-methyl-1h-indol-3-yl-1h-pyrrole-2,5-dione, 1h-pyrrole-2,5-dione, 3-2,4-dichlorophenyl-4-1-methyl-1h-indol-3-yl, 3-2,4-dichlorophenyl-4-1-methylindol-3-yl pyrrole-2,5-dione, 3-2,4-dichlorophenyl-4-1-methylindol-3-yl-1h-pyrrole-2,5-dione, 3-2,4-dichlorophenyl-4-1-methyl-1h-indol-3-yl-2,5-dihydro-1h-pyrrole-2,5-dione, tocris-1616, lopac-s-3442, d0a1yq, sb hplc, 3-2,4-dichlorophenyl-4-1-methyl-1h-indol-3-yl
CN1C=C(C2=CC=CC=C21)C3=C(C(=O)NC3=O)C4=C(C=C(C=C4)Cl)Cl
371.217
371.22
SB 216763
C19H12Cl2N2O2
JCSGFHVFHSKIJH-UHFFFAOYSA-N
3-(2,4-dichlorophenyl)-4-(1-methylindol-3-yl)pyrrole-2,5-dione
176158
>98%
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