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SB 203580, Tocris™

Selective inhibitor of p38 MAPK

Brand:  Tocris (Bio-Techne) 1202/10

Code : Z1

Additional Details : Weight : 0.01000kg

Quantity 10mg

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Product Code. 13488853

  • £194.00 / 10mg


Estimated Shipment
04-01-2018
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Description

Description

Selective inhibitor of p38 MAPK (IC50 values are 50 and 500 nM for SAPK2a/p38 and SAPK2b/p38β2 respectively). Displays 100-500-fold selectivity over LCK, GSK-3β and PKBα. Shown to inhibit IL-2-induced T cell proliferation, cyclooxygenase-1 and -2, and thromboxane synthase. Enhances clonal growth of skin epithelial progenitor cells; stimulates neural stem cell (NSC) proliferation. Essential component of medium for maintaining stem cells in naive pluripotent state. Part of the MAPK Cascade Inhibitor Tocriset™ and MAPK Inhibitor Tocriset™ . Water-soluble salt SB 203580 hydrochloride (Cat. No. 1402) also available.
Specifications

Chemical Identifiers

SB 203580
C21H16FN3OS
377.44
4-[5-(4-Fluorophenyl)-2-[4-(methylsulfonyl)phenyl]-1H-imidazol-4-yl]pyridine

Specifications

SB 203580
152121-47-6
C21H16FN3OS
4-[5-(4-Fluorophenyl)-2-[4-(methylsulfonyl)phenyl]-1H-imidazol-4-yl]pyridine
10mg
>98%
377.44
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