Tocris Bioscience™ RQ 00203078

Potent and selective TRPM8 antagonist; orally active

Description

Potent TRPM8 antagonist (IC50 values are 5.3 and 8.3 nM for rat and human channels respectively). Exhibits >350-fold selectivity for TRPM8 over TRPV4, TRPV1 and TRPA1. Reduces HSC3 and HSC4 oral squamous carcinoma cell migration and invasion in vitro. Also attenuates icilin -induced wet dog shakes in rats. Orally active.

Specifications

• Product Type: RQ 00203078
• Description: RQ 00203078
• Molecular Weight (g/mol): 554.85

For Research Use Only